Valechlorine

Valechlorine
Product Name Valechlorine
CAS No.: 51771-49-4
Catalog No.: CFN90622
Molecular Formula: C22H31ClO8
Molecular Weight: 458.93 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Oil
Targets: Antifection
Source: The herbs of Valeriana officinalis L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Valeranone shows antileishmanial and cytotoxic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Chem Biol Interact.2022, 368:110248.
  • Nat Prod Sci.2019, 25(3):238
  • Eur J Pharmacol.2022, 917:174744.
  • Int J Mol Sci.2020, 21(9):3392.
  • Int J Mol Sci.2023, 24(22):16465.
  • JEJU National University2022, 24032.
  • Anal Chim Acta.2021, 1180:338874.
  • Molecules.2024, 29(5):1048.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Mal J Med Health Sci.2024, 20(SUPP5):151-156.
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    The chloroform extract of Valeriana wallichii (V. wallichii) rhizomes was investigated to elucidate the structures responsible for reported antileishmanial activity. Besides bornyl caffeate (1, already been reported by us previously), bioassay-guided fractionation resulted in two additional cinnamic acid derivatives 2-3 with moderate leishmanicidal activity.
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    The structure of a novel nepetolactone derivative 4 having a cinnamic acid moiety was elucidated by means of spectral analysis. To the best of our knowledge villoside aglycone (5) was isolated from this plant for the first time. The bioassay-guided fractionation yielded two new (compounds 6-7) and two known valtrates (compounds 8-9) with leishmanicidal potential against Leishmania major (L. major) promastigotes. In addition, β-bisabolol (10), α-kessyl alcohol (11), valeranone (12), bornyl isovalerate (13) and linarin-2-O-methylbutyrate (14) were identified.
    CONCLUSIONS:
    This is the first report on the isolation of 4'-demethylpodophyllotoxin (15), podophyllotoxin (16) and pinoresinol (17) in V. wallichii. In total thirteen known and four new compounds were identified from the extract and their cytotoxic and antileishmanial properties were evaluated.
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