Undecanolactone

Fine Chemicals, 2007.

Comparison of the Resolution Performance of Two Kinds of Chiral Capillary Columns towards γ-Lactones.[Reference: WebLink]

The resolution performance of two kinds of chiral capillary columns B-PM and B-TA towards γ-lactones was compared.
METHODS AND RESULTS:
Agilent GC 6890 with FID was used.The conditions were set as injector temperature 250 ℃,detector temperature 250 ℃,N2 as carrier gas,costant flow mode 0.8 mL/min,split ratio 100/1,isothermal 130 ℃ for γ-heptanolactone,γ-octanolactone,γ-nonanolactone and γ-decanolactone,and isothermal 170 ℃ for γ-Undecanolactone and γ-dodecanolactone.The concentration of samples was about w=0.2% in dry ehter;the injection volume was about 0.4 μL.On B-PM,the enantiomers of γ-heptanolactone,γ-octanolactone and γ-nonanolactone were resolved completely with Rs1.5,the enantiomers of γ-decanolactone were separated basically with Rs=1.18,while the enantiomers of γ-Undecanolactone and γ-dodecanolactone couldn′t be separated with Rs1.On B-TA,under the same conditions,the enantiomers of six γ-lactones above could be separated completely with Rs3.

European Journal of Pharmaceutical Sciences, 2012,47(5): 996-1005.

Interactions of inhibitor molecules with the human CYP2E1 enzyme active site.[Reference: WebLink]

CYP2E1 is an important enzyme oxidizing ethanol as well as several drugs and other xenobiotics in the human liver.
METHODS AND RESULTS:
We determined the inhibition potency of structurally diverse compounds against human CYP2E1, and analyzed their interactions with the enzyme active site by molecular docking and 3D-QSAR approaches. The IC50 values for the tested compounds varied from 1.4 μM for γ-Undecanolactone to over 46 mM for glycerol. This data set was used to create a comparative molecular field analysis (CoMFA) model. The most important interactions for binding of inhibitors were identified by docking and key features for inhibitors were characterized via the COMFA model. Since the active site of CYP2E1 is flexible, long chain lactones and alkyl alcohols fitted best into the larger open form while the other compounds fitted better in the smaller closed form of the active site. Electrostatic interactions near the Thr303 residue proved to be important for inhibition of the enzyme activity.
CONCLUSIONS:
Thus, docking analysis and the predictive CoMFA model proved to be efficient tools for revealing interactions between inhibiting compounds and CYP2E1. These approaches can be used to analyze CYP2E1-mediated metabolism and drug interactions in the development of new chemical entities.

The Journal of Chemical Thermodynamics,2014,73: 262-268.

Vapor pressures and enthalpies of vaporization of a series of γ and δ-lactones by correlation gas chromatography.[Reference: WebLink]

METHODS AND RESULTS:
The vaporization enthalpies of γ-octanolactone, γ- and δ-Undecanolactone and γ and δ-dodecanolactone used commercially as flavor ingredients are reported as are their vapor pressures over the temperature range T = (298.15 to 350) K. Vaporization enthalpies at T = 298.15 K of: (66.0 ± 3.9), (79.4 ± 4.4), (80.1 ± 4.5), (83.9 ± 4.6), and (84.61 ± 4.7) kJ · mol−1 and vapor pressures also at T = 298.15 K of: (2.8 ± 0.9), (0.12 ± 0.05), (0.09 ± 0.04), (0.04 ± 0.02), and (0.03 ± 0.02) Pa, respectively, have been evaluated by correlation gas chromatography experiments.
CONCLUSIONS:
The vaporization enthalpies of the lactones studied are reproduced within ±0.5 kJ · mol−1 using a group additivity scheme reported previously for γ- and δ-lactones. The vaporization enthalpies of the γ- and δ-lactones are compared to a similar series of ω-lactones.