Trillikamtoside R
Trillikamtoside R showed cytotoxic effect with an IC50 value of 4.92μM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Bioorg Med Chem Lett. 2017 Jun 1;27(11):2267-2273.
Cytotoxic steroidal saponins from Trillium kamtschaticum.[Pubmed:
28454671 ]
METHODS AND RESULTS:
Eight new steroidal saponins, trillikamtoside K, Trillikamtoside L, Trillikamtoside M, Trillikamtoside N, Trillikamtoside O, Trillikamtoside P, Trillikamtoside Q, Trillikamtoside R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-ol-17-one, which was reported for the first time.
CONCLUSIONS:
The isolated saponins were tested for cytotoxicities against HCT116 cells, and Trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92μM.
