Tomentin

Tomentin
Product Name Tomentin
CAS No.: 28449-62-9
Catalog No.: CFN98347
Molecular Formula: C11H10O5
Molecular Weight: 222.2 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Targets: Immunology & Inflammation related
Source: The barks of Jatropha curcas
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J Agric Food Chem.2024, acs.jafc.4c01387.
  • Translational Neuroscience2024, 15:20220339
  • Mediators Inflamm.2016, 2016:7216912
  • Front Pharmacol.2018, 9:236
  • Pharm Biol.2017, 55(1):360-366
  • Phytomedicine.2021, 2(82):153452
  • Nat Prod Sci.2018, 24(3):206
  • Int J Mol Sci.2021, 22(16):8604.
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    Planta Med. 2014 Feb;80(2-3):209-14.
    Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia.[Pubmed: 24488717 ]
    Sphaeralcea angustifolia, an endangered plant species in Mexico, is employed to treat inflammatory processes and as a wound healing remedy. Scopoletin (1) was reported as one of the main bioactive compounds in this plant.
    METHODS AND RESULTS:
    Here, we isolated and identified compounds with anti-inflammatory properties from the suspension-cultured cells of S. angustifolia. The CH2Cl2 : CH3OH extract of the cells exhibited anti-inflammatory properties in acute inflammation models. Two compounds were isolated, 5-hydroxy-6,7-dimethoxycoumarin, named Tomentin (2), and 2-(1,8-dihydroxy-4-isopropyl-6-methyl-7-methoxy)-naphthoic acid, denominated as sphaeralcic acid (3). Their structures were determined by spectroscopic and spectrometric analyses. The anti-inflammatory effects of both compounds were also evaluated.
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