Tokinolide B
Tokinolide B may have sedative and spasmolytic properties.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Appl Microbiol Biotechnol.2018, 102(12):5105-5120
Pharmacognosy Journal.2022, 14,4,327-337.
J Biomed Sci.2020, 27(1):60.
Biochemistry.2018, 57(40):5886-5896
Acta Pharm Sin B.2015, 5(4):323-9.
Nature Ecology & Evolution2020, doi: 10.1038
Biomed Pharmacother.2024, 179:117365.
Korean J. Medicinal Crop Sci.2023, 31(5):283-289.
Molecules.2019, 24(6):E1177
Korean Herb. Med. Inf.2021, 9(2):231-239.
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Nat Prod Res. 2011 Aug;25(13):1234-42.
Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.[Pubmed:
21797735 ]
METHODS AND RESULTS:
The chemical constituents of the organic extracts from the rhizomes of Ligusticum porteri were isolated, characterised and identified as Z-ligustilide, Z-butylidenephthalide, diligustilide, Tokinolide B, riligustilide, senkyunolides F and I, ferulic acid, among other known compounds. The preparation of 4,5-dehydroTokinolide B from Tokinolide B is reported, and its structure confirmed by X-ray analysis. The sedative and spasmolytic activities of some of these natural products and derivatives were evaluated by applying them to in vivo and in vitro models.
CONCLUSIONS:
Several of these dimeric phthalides displayed sedative and spasmolytic properties that may correlate with some popular uses of L. porteri.
Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2196-201.
Study on biligustilides from Angelica sinensis.[Pubmed:
19166005]
To study the chemical constituents of Angelica sinensis.
METHODS AND RESULTS:
The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis.
Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), Tokinolide B (4), isoTokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides.
CONCLUSIONS:
Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.
