Taraxasterol acetate | CAS:6426-43-3 | Manufacturer ChemFaces

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Naunyn Schmiedebergs Arch Pharmacol. 2014 Feb;387(2):119-27.

Effect of Pluchea lanceolata bioactives in LPS-induced neuroinflammation in C6 rat glial cells.[Pubmed: 24101125]

Neuroinflammation plays a significant role in various chronic and acute pathological conditions of the central nervous system. In the Indian system of medicine, Pluchea lanceolata is used to treat the neurological disorders.
METHODS AND RESULTS:
We investigated the effect of major pentacyclic triterpene and its naturally occurring acetate derivative isolated from P. lanceolata on lipopolysaccharide (LPS)-stimulated neuroinflammatory condition associated to inflammatory cytokine production in rat astrocytoma cell line (C6). The log concentration dependence of Pluchea bioactive taraxasterol (Tx) significantly (p < 0.05) attenuates the release of pro-inflammatory cytokines, such as TNF-α, IFN-γ, and IL-6, while its in situ produced acetyl derivative, i.e., Taraxasterol acetate (TxAc), did not inhibit the LPS-induced IL-6 production at lower concentration (p > 0.05). Surflex-Dock molecular modeling study was performed to simulate the binding capacity of compounds into the active site of the TNF-α (2AZ5), tumor protein P53 (2VUK), and NF-kappa-B (1RAM). The differential inhibition of cytokines by Tx and TxAc was further confirmed by high docking scores showing the high affinity to target proteins.
CONCLUSIONS:
Findings of the study demonstrated the comparatively greater role of Pluchea triterpene than its in situ produced acetate derivate in neuroinflammation-associated disorders.

Acta Botanica Yunnanica, 2007, 29(4):479-482.

Antibacterial triterpenes from Centipeda minima (Compositae).[Reference: WebLink]

METHODS AND RESULTS:
A new triterpene,ursane-20(30)-en-3#beta#, 16#beta#, 21#alpha#-triol(1), together with two known compounds, Taraxasterol acetate(2) and taraxasterol(3), was isolated from the whole plants of Centipeda minima. Their structures were identified by spectroscopic analysis.
CONCLUSIONS:
Antibacterial properties of compounds 2 and 3 were evaluated against eight disease-associated microorganisms by the agar dilution method, Both of them displayed potential antibacterial activities.

Product Name	Taraxasterol acetate
CAS No.:	6426-43-3
Catalog No.:	CFN97104
Molecular Formula:	C₃₂H₅₂O₂
Molecular Weight:	468.8 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Targets:	TNF-α \| IFN-γ \| IL Receptor \| NF-kB
Source:	The roots of Inula britannica L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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