Strychnistenolide

J Nat Prod. 2009 Aug;72(8):1497-501.

Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966 ]

METHODS AND RESULTS:
Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, Strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neolinderalactone, and linderalactone. The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.
CONCLUSIONS:
Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.

J Nat Prod. 2001 Mar;64(3):286-8.

New eudesmane sesquiterpenes from the root of Lindera strychnifolia.[Pubmed: 11277740]

METHODS AND RESULTS:
Strychnistenolide (1) and its acetate 2 were isolated from the root of Lindera strychnifolia, along with a novel rearranged type of secoeudesmane, strychnilactone (3). Their structures were elucidated by extensive analysis of their NMR spectra, including 2D NMR techniques, together with an X-ray analysis for 3.
CONCLUSIONS:
Strychnistenolide exists as a single stereoisomer in CHCl(3), but in pyridine is epimerized.