Forsythoside A

Forsythoside A
Product Name Forsythoside A
CAS No.: 79916-77-1
Catalog No.: CFN99705
Molecular Formula: C29H36O15
Molecular Weight: 624.59 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: White powder
Targets: Antifection | P450 (e.g. CYP17) | P-gp
Source: The fruits of Forsythia suspensa
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $128/20mg
Forsythoside A possesses strong antibacterial, antiinflammatory, antioxidant and antiviral effects. it has the potential to prevent IBV infection in vitro, it can promote the expression of IFN-α and Mx1 significantly.Forsythoside A has inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Fitoterapia. 2018 Jan;
  • J Sci Food Agric. 2017 Mar
  • Food Research InternationalApr. 2018;
  • J Cell Biochem.2018 Feb;
  • J Drug Target.2016 Feb 24:1-28.
  • Plant J. 2017 May;
  • J Ethnopharmacol. 2017 Jul 12;
  • Chem Pharm Bull (Tokyo).2017;65(9)
  • Biol Pharm Bull. 2018;41(1):65-72.
  • Tea Res. Ins. Of ChinaJuly 13, 2017;
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    Phytother Res. 2011 Mar;25(3):338-42.
    Forsythoside a inhibits the avian infectious bronchitis virus in cell culture.[Pubmed: 20677175]
    Forsythoside A is a polyphenolic constituent of the fruits of Forsythia suspensa Vahl. which is widely used as an antiinflammatory agent in traditional Chinese medicine.
    METHODS AND RESULTS:
    In the present study, the effects of Forsythoside A on cell infection by avian infectious bronchitis virus were assessed. A real-time fluorescence quantitative PCR assay was used to determine mRNA content of IBV N gene. The pretreatment of cells with Forsythoside A, adding Forsythoside A post infection of cells, and treatment of virus with Forsythoside A were analysed. The inhibitory effect of Forsythoside A was confirmed by infecting primary chicken embryo kidney cells. Infected cells were inhibited by Forsythoside A treatment.
    CONCLUSIONS:
    The data indicated that Forsythoside A has the potential to prevent IBV infection in vitro.
    Xenobiotica. 2017 Apr;47(4):297-303.
    Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro.[Pubmed: 27310729 ]
    1. Phillyrin and Forsythoside A are two important active ingredients in Forsythia suspensa. However, the effects of phillyrin and Forsythoside A on the activities of cytochrome P450 (CYP450) remain unclear.
    METHODS AND RESULTS:
    2. This study aimed to investigate the effects of phillyrin and Forsythoside A on the activities of CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2 by cocktail probe drugs in rats both in vivo and in vitro. 3. Many pharmacokinetic parameters of caffeine and metoprolol in phillyrin pretreatment group, caffeine and tolbutamide in Forsythoside A pretreatment group were affected significantly. In rat liver microsomal incubation system, the concentrations of acetaminophen and dextrophan in the phillyrin pretreatment group are higher than blank control group by 207.69% and 125.00%, however, the concentrations of 4-hydroxytolbutamide and 6β-hydroxytestosterone were not significantly altered. The concentrations of acetaminophen and 4-hydroxytolbutamide in the Forsythoside A pretreatment group are higher than blank control group by 223.07% and 154.16%, whereas the concentrations of dextrophan and 6β-hydroxytestosterone were not significantly altered.
    CONCLUSIONS:
    4. These results indicated that Phillyrin had potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities. Moreover, Forsythoside A had inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.
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