(+)-Rhododendrol
(+)-Rhododendrol shows anti-inflammatory effects, it can suppress the NO production by activated macrophages in vivo.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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(+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo.[Pubmed:
9810263 ]
METHODS AND RESULTS:
In this study, we investigated the effect of (+)-Rhododendrol (1) and epi-rhododendrin (2) isolated from Acer nikoense Maxim. (Aceraceae) on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guérin and in vitro stimulated by lipopolysaccharide. The NO production was not affected by an oral administration of methanol extract at a dose of 100 mg/kg/day. However, the AcOEt soluble fraction significantly reduced the NO production. (+)-Rhododendrol (1) isolated as an active substance from the AcOEt fraction suppressed the NO production. epi-Rhododendrin (2), the glucoside of (+)-Rhododendrol (1) isolated from the n-BuOH fraction, also suppressed the NO production.
CONCLUSIONS:
As NO is one of the critical mediators in inflammation, these results suggest that (+)-Rhododendrol (1) and epi-rhododendrin (2) contribute in part to the anti-inflammatory effect of A. nikoense.
