Raspberryketone glucoside
Raspberry ketone glucoside has lasting effects for the inhibition of melanogenesis and various melanogenic factors after the degradation in the skin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Separations2023, 10(2), 131.
Russian Journal of Bioorganic Chemistry2023, 49:1689¨C1698.
Herbal Formula Science2024, 32(2):155-179.
Res Pharm Sci.2023, 18(3):244-261.
Nutrients.2019, 11(6):E1380
Food Chem.2023, 404(Pt A):134517.
Front Pharmacol.2019, 10:1355
Drug Des Devel Ther.2020, 14:969-976.
J Pharm Biomed Anal.2024, 251:116444.
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Journal of Society of Cosmetic Chemists of Japan, 2001, 35(2):120-126.
Lasting Effect of Raspberry Ketone Glucoside on Whitening.[Reference:
WebLink]
Tyrosinase is well-known as a key enzyme responsible for the production of melanin in melanocytes. It is also known that inflammatory reactions such as active oxygen species and melanogenic factors in the skin are induced by UV irradiation.
METHODS AND RESULTS:
The keys to suppress melanin synthesis are considered to be not only the inhibition of tyrosinase activity but also that of inflammatory reactions. Raspberryketone glucoside (RKG) in raspberry fruit (Rubus ideaeus) had the inhibitory effect on the melanin synthesis. As a result of an investigation with the glycosides that have similar structure of RKG at its glycoside moieties and alkyl chain, the structure of RKG was found to be suitable as an inhibitory factor on melanogenesis. RKG released raspberry ketone (RK) gradually after the reaction with both homogenated and desquamated cells of the stratum corneum. In addition to the inhibitory effect of melanin synthesis, RK also showed remarkable functions such as the scavenge of nitric oxide (NO) which was considered to induce pigmentation of human skin through activation of melanogenesis and the inhibition of the inflammation-related reactions such as production of superoxide anion and lipid peroxide.
CONCLUSIONS:
These data indicated that RKG had lasting effects for the inhibition of melanogenesis and various melanogenic factors after the degradation in the skin.
