Alisol C monoacetate
Alisol C monoacetate(Alisol C 23-acetate) has antibacterial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Arch. Pharm. Res., 2012, 35(11):1919-26.
A new triterpenoid from Alisma orientale and their antibacterial effect.[Pubmed:
23212633 ]
A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13β,17β-epoxyalisol B 23-acetate (8), 4β,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (Alisol C monoacetate,10), alisolide (11), 16β-methoxyalisol B monoacetate (12), alisol A (13), 16β-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale.
METHODS AND RESULTS:
The structures of compounds (1-15) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5-10 βg/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5-80 μg/mL).
CONCLUSIONS:
Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity.
Chem.Pharm. Bull.,1970,18(7):1369-84.
Biological-Active Triterpenes of Alismatis Rhizoma. IV. The Structures of Alisol B, Alisol B Monoacetate and Alisol C Monoacetate-Some Reactions of the α-Hydroxy Epoxide of the Alisol B Derivatives[Reference:
WebLink]
Studies on the structures of alisol B, alisol B monoacetate and Alisol C monoacetate, the new biological-active triterpenes of Alismatis Rhizoma, are reported.
METHODS AND RESULTS:
The former two compounds have been correlated to alisol A (1) establishing their structures as shown 2 and 4,respectively.
The structure of Alisol C monoacetate has been clarified to be 16-oxoalisol B 23-monoacetate (21) on the basis of correlation of the compound with 4.
Stereochemical courses and mechanisms of some epoxide cleavage reactions of 2,4 and alisol B diacetate (8) are also described.
