Plantagoside

Plantagoside
Product Name Plantagoside
CAS No.: 78708-33-5
Catalog No.: CFN91894
Molecular Formula: C21H22O12
Molecular Weight: 466.39 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: alpha-mannosidase
Source: The herbs of Plantago asiatica
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Plantagoside is a potent inhibitor of the Maillard reaction, it also can inhibit the formation of advanced glycation end products in proteins in physiological conditions and inhibit protein cross-linking glycation. It is also a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50 at 5 microM). Plantagoside suppresses antibody response to sheep red blood cells and concanavalin A induced lymphocyte proliferation which was measured by [3H]thymidine incorporation. Plantagoside has potential therapeutic applications in the prevention of diabetic complications.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Nat Commun.2023, 14(1):4540.
  • Plant Pathology2022, 13527
  • Phytomedicine.2019, 67:153159
  • Journal of Molecular Liquids2022, 364:120062.
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Journal of Pharmaceutical Investigation2024, 024-00662-1.
  • Plant Pathology2022, 10.1111:ppa.13651.
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    METHODS AND RESULTS:
    Plantagoside (5,7,4',5'-tetrahydroxyflavanone-3'-O-glucoside) and its aglycone (5,7,3',4',5'-pentahydroxyflavanone), isolated from a 50% ethanol extract of Plantago major seeds (Plantaginaceae), were established to be potent inhibitors of the Maillard reaction. These compounds also inhibited the formation of advanced glycation end products in proteins in physiological conditions and inhibited protein cross-linking glycation.
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