Paederosidic acid methyl ester | CAS:122413-01-8

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Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.[Pubmed: 19409921]

Antinociceptive activity of Paederosidic acid methyl ester (PAME), a chemical compound isolated from the n-butanol fraction of Paederia scandens, was evaluated in mice using chemical and thermal models of nociception.
METHODS AND RESULTS:
Paederosidic acid methyl ester given by intraperitoneal injection at doses of 20, 40 and 60 mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, Paederosidic acid methyl ester neither significantly enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociceptive activity of Paederosidic acid methyl ester was unlikely due to sedation or motor abnormality. Core body temperature measurement showed that Paederosidic acid methyl ester did not affect temperature within a 2-h period. Moreover, Paederosidic acid methyl ester-induced antinociception in the hot plate test was insensitive to naloxone or nimodipine but significantly antagonized by L-NAME (N (G)-nitro-L-arginine methyl ester), methylene blue and glibenclamide.
CONCLUSIONS:
These results suggested that Paederosidic acid methyl ester-produced antinociception was possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels, which merited further studies regarding the precise site and mechanisms of action.

Product Name	Paederosidic acid methyl ester
CAS No.:	122413-01-8
Catalog No.:	CFN92525
Molecular Formula:	C₁₉H₂₆O₁₂S
Molecular Weight:	478.5 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Targets:	NO \| ATPase \| Potassium Channel
Source:	The herbs of Paederia scandens (Lour.) Merr
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$288/20mg