Paederosidic acid methyl ester
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pharmacol Biochem Behav. 2009 Aug;93(2):97-104.
Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.[Pubmed:
19409921]
Antinociceptive activity of Paederosidic acid methyl ester (PAME), a chemical compound isolated from the n-butanol fraction of Paederia scandens, was evaluated in mice using chemical and thermal models of nociception.
METHODS AND RESULTS:
Paederosidic acid methyl ester given by intraperitoneal injection at doses of 20, 40 and 60 mg/kg produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin or capsaicin injections and on thermal nociception in the tail-flick test and the hot plate test. In the pentobarbital sodium-induced sleep time test and the open-field test, Paederosidic acid methyl ester neither significantly enhanced the pentobarbital sodium-induced sleep time nor impaired the motor performance, indicating that the observed antinociceptive activity of Paederosidic acid methyl ester was unlikely due to sedation or motor abnormality. Core body temperature measurement showed that Paederosidic acid methyl ester did not affect temperature within a 2-h period. Moreover, Paederosidic acid methyl ester-induced antinociception in the hot plate test was insensitive to naloxone or nimodipine but significantly antagonized by L-NAME (N (G)-nitro-L-arginine methyl ester), methylene blue and glibenclamide.
CONCLUSIONS:
These results suggested that Paederosidic acid methyl ester-produced antinociception was possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels, which merited further studies regarding the precise site and mechanisms of action.
