Otosenine
D-Otocenine elicites low toxicity, it shows spasmolytic properties .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Manomaniam Sundaranar University2023, 3859769.
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Heliyon.2022, 8(12):e12031.
Biomed Pharmacother.2022, 146:112497.
Clin Transl Oncol.2019, 10.1007
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Journal of Food Composition and Analysis,2015,42: 1–7.
Hepatotoxic pyrrolizidine alkaloids in Emilia sonchifolia from Taiwan[Reference:
WebLink]
METHODS AND RESULTS:
Otonecine bases, senkirkine, Otosenine, neosenkirkine, petasitenine, acetylsenkirkine, desacetyldoronine, acetylpetasitenine, and doronine. Quantification of the individual PAs was determined by six-point linear regression curves in the range of 25–400 μg/mL of senkirkine and senecionine.
Farmakologiia I Toksikologiia, 1979, 42(5):509-11.
Spasmolytic properties of pyrrolizidine alkaloids[Pubmed:
488324]
METHODS AND RESULTS:
Acute toxicity, spasmolytic and hypotensive properties of the alkaloids senecionine, d-otocenine and floridanin isolated from Senecio Erraticum L. were studied.
CONCLUSIONS:
D-Otocenine and floridanin elicited low toxicity, while senecionine and d-Otosenine showed spasmolytic and floridanin predominantly hypotensive properties.
