Florosenine
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Chromatogr A. 1996 Apr 26;732(1):43-50.
Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography.[Pubmed:
8646334]
METHODS AND RESULTS:
We have applied a high-speed counter-current chromatography (CCC) technique to the separation and purification of pyrrolizidine alkaloids from Amsinckia tessellata, Symphytum spp., Trichodesma incanum (Boraginaceae), and Senecio douglasii var. longilobus (Asteraceae). Alkaloidal fractions were separated in a solvent system composed of a chloroform mobile phase and 0.2 M potassium phosphate buffer, of an optimum pH, as the stationary phase. Up to 800 mg of sample could be successfully separated in a single run, with excellent resolution of alkaloids. Lycopsamine and several of its acetylated derivatives were resolved from alkaloidal fractions of Amsinckia and Symphytum. However, diastereomeric pairs such as 7-acetyl-lycopsamine and 7-acetyl-intermedine, could not be separated. The presence of diastereoisomers was determined by gas chromatography-mass spectrometry. Trichodesma contained predominantly trichodesmine, which was resolved from a small quantity of incanine. we report the electron impact mass spectrum of incanine for the first time.
CONCLUSIONS:
Resolving power of CCC was sufficient to separate the closely related alkaloids senecionine and seneciphylline from Senecio, in addition to Florosenine and retrorsine, Pyrrolizidine alkaloid compositions of the four species, determined by mass spectral techniques, were consistent with literature, except for the lack of riddelliine and the presence of the otonecine-based Florosenine in Senecio douglasii var. longilobus.
Toxicon. 1988;26(3):275-86.
Livestock poisoning in South America by species of the Senecio plant.[Pubmed:
3394160 ]
METHODS AND RESULTS:
The pyrrolizidine alkaloids retrorsine, senecionine, integerrimine, neosenkirkine and Florosenine were isolated from different Senecio spp. common in southern Brazil, Uruguay and Paraguay. Structure elucidation of these compounds was mainly accomplished by two-dimensional FT NMR techniques. Detailed interpretations of 1H-1H and 1H-13C NMR correlation spectra are given.
CONCLUSIONS:
The alkaloids neosenkirkine, integerrimine and Florosenine were found in Senecio leptolobus De Candolle, retrorsine accompanied by senecionine in Senecio selloi (Spreng.) DC and Senecio cisplatinus Cabrera. In Senecio heterotrichus DC. integerrimine is accompanied by retrorsine. Investigations on pathology and histopathology of Senecio envenomation in Brazil are summarized.
