Ophiopogonoside A

J Asian Nat Prod Res. 2012;14(5):491-5.

A new eudesmane sesquiterpene glycosides from Liriope muscari.[Pubmed: 22423627]

METHODS AND RESULTS:
A new eudesmane sesquiterpene glycoside, ophiopogonoside B (1), along with five known compounds, Ophiopogonoside A (2), ruscogenin-1-O-[β-D-glucopyranosyl (1 → 2)]-[β-D-xylopyranosyl (1 → 3)]-β-D-fucopyranoside (3), palmitic acid (4), palmitic acid glyceride (5), and β-sitosterol-D-glucopyranoside (6),was isolated from the tuberous roots of Liriope muscari (Decn.) Bailey (Liliaceae). Their structures were confirmed by 1D and 2D NMR spectroscopy.
CONCLUSIONS:
Among them, compounds 1, 2, 4, and 5 were the first reported from the genus Liriope. Ophiopogonoside B (1) showed moderate inhibitory activity to glycogen phosphorylase a.

J Nat Prod. 2004 Oct;67(10):1761-3.

cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus.[Pubmed: 15497959]

METHODS AND RESULTS:
Two new cis-eudesmane sesquiterpene glycosides, liriopeoside A (1) and Ophiopogonoside A (2), were extracted and purified from tubers of Liriope muscari and Ophiopogon japonicus, respectively, along with three known compounds. Their structures were elucidated as 1beta,6beta-dihydroxy-cis-eudesm-3-ene-6-O-beta-D-glucopyranoside (1) and 1beta,4beta,6beta-trihydroxy-cis-eudesmane-6-O-beta-D-glucopyranoside (2) by spectral data analysis. The structure and the relative configuration of compound 1 were confirmed by X-ray crystallographic analysis.
CONCLUSIONS:
This is the first time that cis-eudesmane-type sesquiterpenes have been reported from the genera Ophiopogon and Liriope.