Onitisin
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Medica, 1985 ,51 (2) :148-50.
Studies on the Taiwan folk medicine; III. A smooth muscle relaxant from Onychium siliculosum, onitin[Reference:
WebLink]
METHODS AND RESULTS:
The pharmacological properties of onitin, onitinoside and Onitisin, three phenolic pterosins, isolated from Onychium siliculosum have been investigated. Their predominant effects are to inhibit the contraction of isolated guinea-pig ileum. In these three compounds, onitin is the most potent one.
CONCLUSIONS:
Onitin (1 × 10-4M) inhibits both the D receptor and M receptor of 5-HT. The antagonism of onitin against histamine is non-competitive.
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):946-50.
Sesquiterpenoids of Coniogramme maxima.[Pubmed:
22792795]
METHODS AND RESULTS:
Fifteen compounds were separated by chromatography technique. Their structures were determined by spectral data, including 10 sesquiterpenoids as (3S)-pteroside D (1), epi-pterosin L (2), pterosin D (3), onitin (4), pterosin Z (5), Onitisin (6), Onitisin-glucopyranoside (7), onitin-15-O-beta-D-glucopyranoside (8), (2S,3R)-pterosin-L-2'-O-beta-D-glucopyranoside (9) and (3R)-peterosin D-3-O-beta-D-glucopyranoside (10). The other compounds were uracil (11), 3,4-dihydroxybenzaldehyde (12), 5-hydroxymethyl-2-furancarboxaldehyde (13), beta-sitosterol (14) and daucosterol (15).
CONCLUSIONS:
The above 15 compounds are separated from C. maxima for the first time, including 9 compounds being first separated from genus Coniogramme.
