(Z)-23-Coumaroylhederagenin
(Z)-23-Coumaroylhederagenin shows significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and the IC(50) value in the range 1.2-3.6 microM.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Front Pharmacol.2022, 13:806869.
Food Chem.2019, 278:683-691
Phytother Res.2022, ptr.7573.
Phytomedicine Plus2022, 2(1):100207.
Molecules.2021, 26(18):5665.
AMB Express2020. 10(1):126.
Nutrients.2020, 12(11):3448.
Int J Biol Macromol.2018, 112:1093-1103
bioRxiv - Biochemistry2023, 541790.
J Biomol Struct Dyn.2022, 1-21.
Related and Featured Products
J Nat Prod. 2004 Jan;67(1):91-3.
Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines.[Pubmed:
14738395 ]
METHODS AND RESULTS:
Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin ((Z)-23-Coumaroylhederagenin,1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods.
CONCLUSIONS:
All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC(50) values in the range 1.2-3.6 microM.
