Odorine

Odorine
Product Name Odorine
CAS No.: 72755-20-5
Catalog No.: CFN97210
Molecular Formula: C18H24N2O2
Molecular Weight: 300.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Aglaia odorata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • Antioxidants (Basel).2022, 11(12):2496.
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Ethnomedicinal Plants for Drug Discovery2024, 491-509
  • Eur J Pharmacol.2018, 832:96-103
  • Bioorg Med Chem.2020, 28(12):115553.
  • Sci Rep.2017, 7:46299
  • The Journal of Korean Medicine2023, 44(4):26-40.
  • Thorac Cancer.2023, 14(21):2007-2017.
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    Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.[Pubmed: 11725964]

    METHODS AND RESULTS:
    In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, Odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter.
    CONCLUSIONS:
    From these results, it was concluded that Odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.
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