Nyasicoside

Nyasicoside
Product Name Nyasicoside
CAS No.: 111518-94-6
Catalog No.: CFN99212
Molecular Formula: C23H26O11
Molecular Weight: 478.5 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Curculigo capitulata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Nyasicoside may have promising and beneficial thrombolytic activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Journal of Chromatography A2020, 460942
  • LWT2021, 138:110630.
  • Appl. Sci.2023, 13(17), 9653.
  • Sci Rep.2019, 9(1):6429
  • J Chromatogr A.2022, 1685:463640.
  • Biochem Pharmacol.2017, 130:10-20
  • Biomed Pharmacother.2019, 116:108987
  • Evid-Based Compl Alt2020, 7202519:13
  • Molecules.2020, 25(9):2081.
  • Int J Mol Sci.2022, 23(11):6104.
  • 1,5-Epoxy-3R-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane

    Catalog No: CFN95857
    CAS No: 182227-93-6
    Price: $318/5mg
    1,5-Epoxy-3S-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane

    Catalog No: CFN95858
    CAS No: 182369-54-6
    Price: $368/5mg
    4'-O-Methylnyasol

    Catalog No: CFN89281
    CAS No: 79004-25-4
    Price: $318/5mg
    3'-Methoxynyasin

    Catalog No: CFN95870
    CAS No: 1685246-20-1
    Price: $318/5mg
    Nyasicol

    Catalog No: CFN99213
    CAS No: 111518-95-7
    Price: Inquiry(manager@chemfaces.com)
    Nyasicol 1,2-acetonide

    Catalog No: CFN96568
    CAS No: 1432057-64-1
    Price: Inquiry(manager@chemfaces.com)
    Nyasicoside

    Catalog No: CFN99212
    CAS No: 111518-94-6
    Price: Inquiry(manager@chemfaces.com)
    Pilosidine

    Catalog No: CFN95110
    CAS No: 229971-57-7
    Price: $413/5mg
    4-(3,5-Dihydroxy-7-(4-hydroxy-3-methoxyphenyl)heptyl)benzene-1,2-diol

    Catalog No: CFN95879
    CAS No: 884495-94-7
    Price: $318/10mg
    Octahydrocurcumin

    Catalog No: CFN90584
    CAS No: 36062-07-4
    Price: $388/20mg
    J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):659-66.
    Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds.[Pubmed: 27371821]
    This study aims to investigate whether tested organic extracts possess antithrombotic properties with minimal or no toxicity and to predict the activity of some of their isolated compounds.
    METHODS AND RESULTS:
    An in vitro thrombolytic model was used to check the clot lysis effect of four Bangladeshi herbal extracts viz., roots ofCurculigo recurvataW.T. Aiton (Satipata), leaf ofAmorphophallus bulbiferRoxb. (Olkachu), leaf ofPhyllanthus sikkimensisMuell. Arg., and whole plant ofThunbergia grandifloraRoxb. (Nillata) using streptokinase as a positive control and water as a negative control. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate as positive control. In silico prediction of activity spectra for substances (PASS) prediction was applied for phytoconstituents, namely, Nyasicoside, glucomannan, grandifloric acid, serine, and alanine. Using an in vitro thrombolytic model,C. recurvata,A. bulbifer,P. sikkimensis, andT. grandiflorashowed 28.10±1.64%, 42.47±1.96%, 32.86±1.92%, and 25.51±1.67% of clot lysis, respectively. Reference drug streptokinase exhibited 75.00±3.04% clot lysis. Examined herbs showed significant (p<0.001) percentage (%) of clot lysis compared to negative control. In brine shrimp cytotoxic assay,C. recurvata,A. bulbifer,P. sikkimensis, andT. grandiflorashowed LC50values 210.64±3.44, 98.51±1.47, 187.29±2.01, and 386.43±3.02 μg/mL, respectively, with reference to vincristine sulfate (LC500.76±0.04). PASS predicted that examined phytoconstituents have a wide range of biological activity.
    CONCLUSIONS:
    Through our study it was found thatA. bulbiferandP. sikkimensiscould be considered as very promising and beneficial thrombolytic agents.
    J Nat Prod. 1999 May;62(5):734-9.
    Three novel constituents from curculigo capitulata and revision of C-2 stereochemistry in nyasicoside.[Pubmed: 10346957]

    METHODS AND RESULTS:
    Continuing study of the constituents of the rhizomes of Curculigo capitulata provided three novel compounds, including two norlignan glucosides, curcapicycloside (2) and (1S,2R)-O-methylNyasicoside (3), and a phenanthrofuran, curcapital (9). The former two compounds were characterized as their tetra-O-methyl derivatives. Compound 2 possesses a glucosyl-fused skeleton with 1R,2R configuration. Biogenetic consideration led to a revision of the previously assigned 2S configuration of Nyasicoside (1) to 2R, which was confirmed by NOE studies of the acetonide of its tetra-O-methyl derivative. The 2R configuration in tetra-O-methyl-1-O-methyl curculigine (7a) and isocurculigine (8a) was also established by chemical correlation of the former with (1R, 2R)-tetra-O-methyl-1-O-methylNyasicoside (10a).
    CONCLUSIONS:
    Curcapital (9) represents the first natural product having a phenanthro[9,10, b]furan skeleton.
    (Z)-Aldosecologanin (Centauroside)

    Catalog No: CFN95079
    CAS No: 82474-97-3
    Price: $388/5mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    Complanatoside C

    Catalog No: CFN95144
    CAS No: N/A
    Price: $318/5mg
    Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside

    Catalog No: CFN95157
    CAS No: 1147858-78-3
    Price: $318/10mg
    (E)-6-O-(p-coumaroyl)scandoside methyl ester

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg
    Arisanschinin E

    Catalog No: CFN95221
    CAS No: 1333378-33-8
    Price: Inquiry(manager@chemfaces.com)
    Indolelactic acid

    Catalog No: CFN95263
    CAS No: 1821-52-9
    Price: $100/20mg
    Oleracein E

    Catalog No: CFN95441
    CAS No: 1021950-79-7
    Price: $318/5mg
    Sophoraflavone A

    Catalog No: CFN95510
    CAS No: 105594-08-9
    Price: $318/10mg
    Octyl 3-(4-hydroxyphenyl)prop-2-enoate

    Catalog No: CFN95563
    CAS No: N/A
    Price: $318/5mg