Tetramethylcurcumin
Tetramethylcurcumin is a natural product from Curcuma rcenyujin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 15;949-950:70-8.
A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.[Reference:
WebLink]
METHODS AND RESULTS:
Recently, we characterized the mass spectra of curcumin, its two synthetic analogs Tetramethylcurcumin (TMC) and dimethylcyclohexyl curcumin (DMCHC), and its two metabolites tetrahydrocurcumin (THC) and curcumin O-glucuronide (COG) under a positive ion mode on a Thermo TSQ Quantum triple quadrupole mass spectrometer [9,10].
CONCLUSIONS:
The protonated molecular ions are the predominant ions in their respective mass spectra; the major fragmentation pathway for curcumin, THC, TMC, and DMCHC is the cleavage of the heptenoid chain between the 3rd and the 4th carbon atoms (Scheme 1) [9]; and the major fragmentation for COG is glycosidic cleavage (Scheme 1) [10]. Two analytic methods for quantification of curcuminoids and COG [10] were established in both mouse and human plasma under a positive mode.
