Nirtetralin
Nirtetralin suppresses effectively both HBsAg and HBeAg expression.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytother Res. 2012 Jul;26(7):964-8.
Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L.[Pubmed:
22131154]
One new lignan, Nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L.
METHODS AND RESULTS:
The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis.
These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and Nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (Nirtetralin A), 16.7 µM (Nirtetralin B) and 97.2 µM (Nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (Nirtetralin A), 69.3 µM (Nirtetralin B) and 232.0 µM (Nirtetralin), respectively.
Phytother Res. 2003 May;17(5):449-53.
Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.[Pubmed:
12748977 ]
CONCLUSIONS:
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), Nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively.
CONCLUSIONS:
Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
