Neocaesalpin O
Neocaesalpin O is a natural product from Caesalpinia minax HANCE.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chulalongkorn University2024, 4761190
Molecular Simulation2023, 49(8):799-815.
Korean J. Food Preserv.2023, 30(4):663-668.
Int J Mol Sci.2022, 23(11):6172.
Mol Pharmacol.2021, 99(2):163-174.
Institut Pasteur Korea2020, doi: 10.21203.
The Thai Journal of Pharmaceutical Sciences2023, 47(3):3.
South African J of Botany2020, 135:50-57
Curr Top Med Chem.2020, 20(21):1898-1909.
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Chem Pharm Bull (Tokyo). 2012;60(6):759-63.
The new cassane-type diterpenes from Caesalpinia minax.[Pubmed:
22689428]
METHODS AND RESULTS:
Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis.
CONCLUSIONS:
Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.
