Mulberrofuran K
Mulberrofuran K shows potent anti-oxidation activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Biol Chem.2014, 289(3):1723-31
Nat Commun.2023 Dec 20;14(1):8457.
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Mol Plant Pathol.2022, 10.1111:mpp.13280.
Int J Mol Sci.2021, 22(8):4211.
Separations2023, 10(4), 231.
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Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1569-72.
Study of anti-oxidant phenolic compounds from stem barks of Morus yunanensis.[Pubmed:
18837317]
To study anti-oxidant phenolic compounds from stem barks of Morus yunanensis.
METHODS AND RESULTS:
Isolation and purification were carried out by silica gel, Sephadex LH -20 and RP - 18 column chromatography. The chemical structures of constituents were elucidated on the basis of physicochemical properties and spectral data. Eight phenolic compounds were isolated and identified as: mulberrofuran E (1), Mulberrofuran K (2), albanol B (3), kuwanon H (4), resveratrol (5), moracin M (6), morachalcone A (7), 3', 5', 2, 4-tetrahydroxy-4-(3-methyl-1-butenyl) stilbene (8).
CONCLUSIONS:
All the compounds were isolated from the plant for the first time, and compounds 2, 3, 6, 8 showed potent anti-oxidation activities.
Planta Med. 2007 Nov;73(14):1481-5.
Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.[Pubmed:
17948170]
Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection.
METHODS AND RESULTS:
In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five compounds, mulberroside C ( 1), moracin P ( 2), moracin O ( 3), moracin M ( 4) and Mulberrofuran K ( 5) from the ethyl acetate-soluble fraction.
CONCLUSIONS:
Compounds 1 approximately 4 showed significant inhibitory activities. Compounds 2 and 3 showed potent inhibitory activity (IC (50) 35.6 microM, 80.8 microM, respectively) in the replicon cell assay, which was confirmed by NS3 helicase inhibitory activity (IC (50) 42.9 microM, 27.0 microM, respectively).
