Methyl 3-carbazolecarboxylate
Methyl 3-carbazolecarboxylate is a natural product from Micromelum sp.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chem Biol Interact.2016, 258:59-68
Cancers (Basel).2023, 15(1):37.
Chinese Medicine2019, 14(1)
Am J Chin Med.2016, 44(8):1719-1735
Separations2023, 10(11), 567;
Anal Bioanal Chem. 2025, 417(17):3879-3892.
Journal of Molecular Liquids2021, 334:116014.
Mol Biol Rep.2023, 50(5):4029-4038.
Mol Med Rep.2024, 29(2):26.
Environ Toxicol.2019, 34(4):513-520.
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Planta Med. 2005 Mar;71(3):261-7.
Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum.[Pubmed:
15770548 ]
METHODS AND RESULTS:
Anti-TB bioassay-directed fractionation led to the isolation of six carbazole alkaloids, as well as the gamma-lactone derivative of oleic acid, from the CH (2)Cl (2) extract of the stem bark of Micromelum hirsutum. The carbazoles include the new micromeline ( 2) and five known alkaloids: lansine ( 3), 3-methylcarbazole ( 4), methyl carbazole-3-carboxylate ( Methyl 3-carbazolecarboxylate,5), 3-formylcarbazole ( 6), and 3-formyl-6-methoxycarbazole ( 7). Compound 1 was identified as the lactone derivative of oleic acid, (-)- Z-9-octadecene-4-olide, for which the trivial name micromolide ( 1) is suggested. It showed potent in vitro anti-TB activity against H37R v (MIC: 1.5 microg/mL), a selectivity index (SI) of 63, and exhibited activity against the Erdman strain of M. tuberculosis in a J774 mouse macrophage model (EC (90) : 5.6 microg/mL).
CONCLUSIONS:
Thus, 1 appears worthy of further evaluation as a potential new anti-TB agent. Isolates 2, 3, 6 and 7 had anti-TB MIC values between 14.3 and 42.3 microg/mL, while compounds 4 and 5 were considered inactive (MIC > 128 microg/mL). Structure elucidation and identification were based on spectroscopic analysis, including MS, 1D/2D NMR, and a full (1)H spin system analysis of 1.
