Longiferone B
Longiferone B shows anti-inflammatory activity against NO release with IC50 values of 21.0 uM, it also suppresses the iNOS and COX-2 mRNA expression.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Eur J Pharmacol.2024, 975:176644.
Food Chem Toxicol.2023, 176:113802.
Nutrients.2021, 13(12):4364.
J Inflamm Res.2022, 15:5347-5359.
Preprints2022, 202211.0388.v1.
Pak J Pharm Sci.2019, 32(6):2879-2885
J Microbiol Biotechnol.2024, 35:e2408022.
Jeju National University Graduate School2023, 24478
Antioxidants.2022, 11(3):592.
Molecules.2019, 24(17):E3127
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J Ethnopharmacol. 2014 Jun 11;154(2):453-61
Anti-inflammatory activity of compounds from Boesenbergia longiflora rhizomes.[Pubmed:
24786574 ]
METHODS AND RESULTS:
The isolation of the CHCl3 fraction from Boesenbergia longiflora rhizomes led to the isolation of three new daucane sesquiterpenes, which were identified as 8-hydroxy-dauca-9, 11-diene-7-one (longiferone A; 1), dauca-8, 11-diene-7-one (Longiferone B; 2) and dauca-8, 11-diene-7, 10-dione (longiferone C; 3); together with four known flavonoids, six known diarylheptanoids as well as one sterol. The Longiferone B (2) and longiferone C (3) showed anti-inflammatory activity against NO release with IC50 values of 21.0 and 31.3μM, respectively. Longiferone B (2) also suppressed the iNOS and COX-2 mRNA expression. Moreover, the flavonoids and diarylheptanoids inhibited NO and TNF-α production in a dose dependent manner.
CONCLUSIONS:
This study demonstrated that sesquiterpenes, diarylheptanoids and some methoxyflavonoids found in Boesenbergia longiflora are responsible for anti-inflammatory activity.
