Leucodin
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
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Int J Mol Sci.2021, 22(21):11447.
Food Chemistry: X2023, 101032.
Evid Based Complement Alternat Med.2020, 2020:8582318.
Antioxidants (Basel).2021, 10(9):1487.
Sci Rep.2018, 8(1):12970
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Molecules. 2016 Mar 25;21(4):404.
The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed:
27023504 ]
METHODS AND RESULTS:
The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
CONCLUSIONS:
Out of the five compounds in the CF, 1β,10β-epoxydesacetoxymatricarin (CP1) and Leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.
Planta Med. 1998 Aug;64(6):577-8.
Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.[Pubmed:
9741305]
METHODS AND RESULTS:
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property.
CONCLUSIONS:
It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and Leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.
Nat Prod Res. 2012;26(20):1892-7.
A new triterpene from Scorzonera latifolia (Fisch. and Mey.) DC.[Pubmed:
21995805]
METHODS AND RESULTS:
A novel triterpene 1 (3-β-hydroxy-fern-7-en-6-one-acetate) together with four known compounds, urs-12-en-11-one-3-acetyl (2), 3-β-hydroxy-fern-8-en-7-one-acetate (3), olean-12-en-11-one-3-acetyl (4) and Leucodin (5) were obtained from the S. latifolia roots. All compounds were isolated from the n-hexane extract of S. latifolia roots using several chromatographic techniques.
CONCLUSIONS:
The structure of the isolated compounds was elucidated on the basis of (1)H-NMR, (13)C-NMR and 2D NMR data (HMBC, HMQC, COSY, TOCSY, NOESY, DEPT) as well as GC EITOF-HRMS.
