Leptomerine

Leptomerine
Product Name Leptomerine
CAS No.: 22048-97-1
Catalog No.: CFN90841
Molecular Formula: C13H15NO
Molecular Weight: 201.3 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: AChR
Source: The herbs of Haplophyllum leptomerum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $208/10mg
Leptomerine (IC₅₀ = 2.5 mM) shows potent anticholinesterasic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules 2021, 26(4),1092.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Preprints2017, 2017120176
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Phytother Res.2020, 34(4):788-795.
  • Int J Mol Sci.2020, 21(19):7209.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Horticulturae2024, 10(5), 486.
  • Metabolites2022, 12(6),507.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
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    Molecules. 2010 Dec 13;15(12):9205-13.
    Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease.[Pubmed: 21160449]
    Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil.
    METHODS AND RESULTS:
    Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC₅₀ = 2.5 mM), similar to that of the reference compound galanthamine (IC₅₀ = 1.7 mM).
    CONCLUSIONS:
    The results showed for the first time the presence of alkaloids Leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
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