Kushenol E
Kushenol E exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biol Pharm Bull. 2008 May;31(5):908-15.
Re-evaluation of the antioxidant prenylated flavonoids from the roots of Sophora flavescens.[Pubmed:
18451517]
This was in contrast to the prenylated flavanones, sophoraflavanone G and kurarinone, which were isolated from the methylene chloride (CH(2)Cl(2)) fraction of the same source.
METHODS AND RESULTS:
Five flavanones consisting of Kushenol E, leachianone G, kurarinol, sophoraflavanone G, and kurarinone exhibited significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays; however, the prenylated chalcones and prenylated flavonol showed more potent scavenging/inhibitory activities than the prenylated flavanones. Therefore, the prenylated chalcones and prenylated flavonol, rather than the prenylated flavanones, may make important contributions toward the marked antioxidant capacities of S. flavescens. Furthermore, kuraridinol, kurarinol, and kurarinone showed significant inhibitory activities against intracellular ROS levels as well as NF-kappaB activation by t-BHP.
CONCLUSIONS:
Overall, the results indicate that S. flavescens and its prenylated flavonoids may possess good anti-inflammatory activity, which is implicated in their significant antioxidant activity.
World Journal of Pharmaceutical Research, 2016 , 5990 (2) :274-83.
IN SILICO PASS PREDICTION AND MOLECULAR DOCKING OF ISOLATED COMPOUNDS FROM FLEMINGIA MACROPHYLLA FOR THROMBOLYTIC EFFECT[Reference:
WebLink]
METHODS AND RESULTS:
A wide range of docking score found during molecular docking by CPI server. Beta-sitosterol, cajanin, flemichin E, flemiflavanone A, genistein, genistin, Kushenol E, neoraufurane and prunetin showed the docking score -7.9, -8.4, -8.8, -8.6, -8.0, -8.6, -8.7, -8.3 and -7.9, respectively.
CONCLUSIONS:
Data from the both in silico models showed similar values for the same compound, because flemichin E showed high value and beta-sitosterol, prunetin showed low value in both in silico models.
