Khasianine

Khasianine
Product Name Khasianine
CAS No.: 32449-98-2
Catalog No.: CFN90387
Molecular Formula: C39H63NO11
Molecular Weight: 721.93 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Solanum nigrum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $168/20mg
Khasianine exhibits strong activity against liver damage induced by CCl4.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Biochem Biophys Res Commun. 1998 Jan 6;242(1):21-5.
    The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis.[Pubmed: 9439603]
    Solamargine, solasodine and Khasianine steroidal alkaloids are utilized to determine the role of carbohydrate moiety in the mechanism of apoptosis.
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    The C3 side chain of solamargine, Khasianine and solasodine contains 4'Rha-Glc-Rha2', 4'Rha-Glc and H, respectively. Solamargine possessed potent cytotoxicity to human hepatoma cells, while the cytotoxicity of Khasianine was greatly diminished. Nevertheless, only solamargine could induced "sub-G1" of apoptotic feature in flowcytometry. Thus, the 2'Rha moiety of solamargine may play a crucial role in triggering cell death by apoptosis. In addition, the molecular modeling of solamargine indicated that the 2'Rha moiety was adjacent to the rigid steroid structure, and drastically changed the dihedral angle of the glycosidic bond.
    CONCLUSIONS:
    The regulations of TNFR I and II expression by different carbohydrate moieties were also distinct. It implied that the carbohydrate moieties of steroidal alkaloids might alter the binding specificity to steroid receptors and consequently regulate the gene expression in different manners.
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