Isochlorogenic acid C(4,5)
Isochlorogenic acid C(4,5) has antiviral activity, including anti-HIV-1 integrase activity. It shows anti-hepatotoxic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Journal of Pharmaceutical Analysis, 2016.
Simultaneous determination of isochlorogenic acid A, sochlorogenic acid B,and sochlorogenic acid C in crude and sweated Radix Dipsaci by HPLC.[Reference:
WebLink]
To study the effects of primary processing“sweating”on the contents of isochlorogenic acid A,isochlorogenic acid B,and isochlorogenic acid C in crude and sweated Radix Dipsaci.
METHODS AND RESULTS:
The simultaneous determination method of isochlorogenic acid A,isochlorogenic acid B and isochlorogenic acid C in crude and sweated Radix Dipsaci were developed by using high performance liquid chromatography (HPLC), and then the determination results before and after sweating process were compared and analyzed.The sample solution was determined by HPLC with an Agilent Eclipse XDB- C18 column(250 mm×4.6 mm,5 μm).The acetonitrile(A)-0.05% phosphoric acid water solution(B) was applied as the mobile phase by gradient elution(0~5 min,2%A→6%A;5~18 min,6%A→10%A;18~40 min,10%A→20%A;40~70 min,20%A→25%A;70~80 min,25%A→35%A;80~90 min,35%A→60%A;90~110 min,60%A→70%A;110~120 min,70%A).The analyses were performed at 30°C with a flow rate of 1 mL·min-1,and the UV detection was performed at 212 nm. Isochlorogenic acid B,isochlorogenic acid A and isochlorogenic acid C showed good linearity (r≥0.999 8) in the range of the tested concentration,while the average recoveries(n=6) of isochlorogenic acid B,isochlorogenic acid A and isochlorogenic acid C were 101.5%,101.7% and 102.0%,respectively.The contents of the three compositions in crude Radix Dipsaci from different places of production were 0.06%-0.13%,0.45%-0.92% and 0.18%-0.73%,respectively;and the ones in sweated samples were 0.09%-0.76%,0.29%-0.88% and 0.24%-0.80%,respectively.Through primary processing“sweating”,both of the contents of isochlorogenic acid B and isochlorogenic acid C were increased,and isochlorogenic acid A was decreased.
CONCLUSIONS:
The results demonstrated that primary processing“sweating”indeed had an effect on the contents of isochlorogenic acid A,isochlorogenic acid B and isochlorogenic acid C,which provided proof for the further study of the“sweating”mechanism and process of Radix Dipsaci.
