Hispanone
Hispanone possesses anti-inflammatory activity, it shows inhibition of superoxide anion generation and elastase release.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Research Square2022, rs.3.rs-1948239
Sci Rep.2019, 9:12132
Phytomedicine.2022, 102:154183.
Academic J of Second Military Medical University2018, 39(11)
Toxicol Appl Pharmacol.2022, 434:115815.
BMC Complement Med Ther. 2020, 20(1):91.
Front Pharmacol.2021, 12:765521.
J Nat Prod.2019, 82(4):1002-1008
Toxicol In Vitro.2023, 93:105667.
Front Pharmacol.2022, 13:806869.
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Phytochemistry Letters, 2014, 10:313-317.
New labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity.[Reference:
WebLink]
METHODS AND RESULTS:
Two new, 16-oxo-leoheteronone A (1) and 15-methoxyleoheteronin B (2), and four known, 8,9-secohispanolone (3), galeopsin (4), Hispanone (5), and leoheteronin B (6), labdane diterpenoids were isolated from the aerial parts of Leonurus japonicus. Compound 3 was isolated for the first time as a naturally occurring compound.
CONCLUSIONS:
Structures of the two compounds were determined on the basis of extensive spectroscopic techniques, including 1D, 2D NMR, and HREIMS. In addition, compounds 1–3, 5 and 6 were examined for inhibition of superoxide anion generation and elastase release, and the results suggested that compound 5 possesses anti-inflammatory activity.
