Gomisin O
Gomisin O is a natural product from Schizandra chinensis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chemical & pharmaceutical bulletin 27(11), 2695-2709, 1979-11-25
The Constituents of Schizandra chinensis BAILL. V. The Structures of Four New Lignans, Gomisin N, Gomisin O, Epigomisin O and Gomisin E, and Transformation of Gomisin N to Deangeloylgomisin B[Reference:
WebLink]
Four new dibenzocyclooctadiene lignans, gomisin N (1), Gomisin O (2) and gomisin E (4), and epiGomisin O (3), together with a known lignan (+)-deoxyschizandrin (5) were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae).
METHODS AND RESULTS:
The structures of the new lignans were elucidated by chemical and spectral studies. The transformation of 1 to deangeloylgomisin B (debenzoylgomisin C) (6) is also described.
J Org Chem. 2005 Oct 28;70(22):8932-41.
Asymmetric total synthesis of dibenzocyclooctadiene lignan natural products.[Pubmed:
16238330 ]
Full details of the asymmetric total syntheses of the dibenzocyclooctadiene lignans interiotherin A, angeloylgomisin R, Gomisin O, and gomisin E (epiGomisin O) are presented.
METHODS AND RESULTS:
The syntheses were based on a unified synthetic strategy involving a novel crotylation using the Leighton auxiliary that occurred with excellent asymmetric induction (>98:2 enantiomeric ratio), a diastereoselective hydroboration/Suzuki-Miyaura coupling reaction sequence, and an atropdiastereoselective biarylcuprate coupling, both of which occurred with total (>20:1) stereocontrol.
The syntheses were achieved in six to eight steps from simple aromatic precursors.
