Globularin
Globularin has hypoglycaemic and hypolipidemic activities in normal and streptozotocin-induced diabetic rats.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytochemistry. 2003 Sep;64(2):529-33.
Aragoside and iridoid glucosides from Aragoa cundinamarcensis.[Pubmed:
12943770]
METHODS AND RESULTS:
From the water-soluble part of an extract of Aragoa cundinamarcensis were isolated seven iridoid glucosides, namely aucubin, catalpol, rehmannioside D, Globularin, gardoside methyl ester, epiloganin and mussaenoside. The main glycoside isolated, however, was a new caffeoyl phenylethanoid triglycoside, named aragoside, containing two beta-gluco- and one alpha-arabinopyranosyl moieties which constituted almost 5% of the dry weight of the plant. Finally, sorbitol was found to be the main carbohydrate constituent of the plant. This distinctive combination of compounds is very similar to that reported from some species of Plantago.
CONCLUSIONS:
The present findings therefore support the results from a recently published molecular phylogenetic study of plastid and nuclear ribosomal DNA sequences, where Aragoa was found to be the closest relative to Plantago so far discovered.
J. Appl. Pharm.Sci., 2013,03(4):001-7.
Evaluation of hypoglycaemic and hypolipidemic activities of Globularin isolated from Globularia alypum L. In normal and streptozotocin-induced diabetic rats[Reference:
WebLink]
The present study investigates the effect of intraperitoneal administration of Globularin on blood glucose levelsin normal and streptozotocin diabetic rats.
METHODS AND RESULTS:
Globularin was an iridoid glucoside which was isolated from theleaves of Globularia alypum (3.4 %). This compound was identified by means of physical constants andspectral data UV, IR, MS, 1H-NMR, 13C-NMR, DEPT, COSY, HMBC. The acute toxicity test demonstrated thatGlobularin is not lethal up to dose of 1000 mg/kg body weight after intraperitoneal injection. In normal andstreptozotocin diabetic rats, single intraperitoneal administration of Globularin at a dose 100 mg/kg body weightproduced significant decrease of blood glucose levels. However, in prolonged treatment study, the repeatedintraperitoneal administration of Globularin (2 x 100 mg/kg body weight) decreased significantly the bloodglucose levels when compared to the diabetic control rats. In addition, daily injection of Globularin (2 x 100mg/kg body weight) reduced significantly serum levels of total cholesterol (varied from 0.53 to 0.41 g/L) andtriglycerides (varied from 1.71 to 0.79 g/L) in the diabetic rats.
Chem Pharm Bull (Tokyo). 2006 Jan;54(1):85-8.
Iridoid glucosides from the aerial parts of Globularia alypum L. (Globulariaceae).[Pubmed:
16394555]
METHODS AND RESULTS:
From the hydromethanolic extract of the aerial parts of Globularia alypum grown in Morocco, a new chlorinated iridoid glucoside, globularioside has been isolated beside 5 known iridoid glycosides, Globularin, globularicisin, globularidin, Globularinin and globularimin. This is the first report of a chlorinated iridoid in G. alypum and in the Globulareaceae. Unlike all other known 7-chlorinated iridoid glucosides where the chlorine atom exhibits an alpha configuration, globularioside incorporate the chlorine atom as a 7beta substituent.
CONCLUSIONS:
The structures of the isolated compounds were established on the basis of ESI-MS, MS-MS, 1D and 2D NMR spectral analysis.
