Rehmannioside A
Rehmannioside A is an iridoid glucoside.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Yao Xue Xue Bao. 2013 Sep;48(9):1464-70.
Absorption and pharmacokinetics of radix rehmanniae in rats.[Pubmed:
24358782]
In this paper, absorption and pharmacokinetic study of Radix Rehmanniae was studied by liquid chromatography coupled with mass spectrometry method after oral administration to rats.
METHODS AND RESULTS:
By comparing the chromatograms of ultraviolet, full scan, extracted ion and selective reaction monitoring (SRM) of standard solution, Radix Rehmanniae, blank plasma and rat plasma post drug administration, catalpol and ajugol were found to be the main compounds absorbed from Radix Rehmanniae. Plasma concentrations of aucubin, dihydrocatalpol, Rehmannioside A (or rehmannioside B/ melittoside) and rehmannioside D were very low. Quantitative method for catalpol and aucubin and semi-quantitative method for other compounds in rat plasma were established.
The pharmacokinetic study of those absorbed components was conducted after oral administration of 6 g x kg(-1) Radix Rehmanniae water extract to rats.
CONCLUSIONS:
Cmax, t(1/2) and AUC(0-infinity) of catalpol and ajugol were (2349.05 +/- 1438.34) and (104.25 +/- 82.05) ng x mL(-1), (0.86 +/- 0.32) and (0.96 +/- 0.37) h, (4407.58 +/- 2734.89) and (226.66 +/- 188.38) ng x h x mL(-1), respectively. tmax was at 1.00 h for catalpol and ajugol. Both catalpol and ajugol were absorbed and excreted rapidly.
Journal of Shenyang Pharmaceutical University, 2013 , 30 (7) :506-8.
Isolation and identification of the chemical constituents from Rehmannia glutinosa L.[Reference:
WebLink]
To study the chemical constituents from Rehmannia glutinosa.
METHODS AND RESULTS:
Compounds were isolated by chromatography on silica gel,Sephadex LH-20 and PHPLC.Their structures were confirmed on the basis of physico-chemical constants and spectroscopic analysis.Ten compounds were isolated and their structures were identified as 7-isoquinolinol(1),5-hydroxy-2-pyridinemethanol(2),6-methyl-3-pyridinol(3),salidroside(4),rehmanniosid C(5),Rehmannioside A(6),adenosine(7),adenine(8),uridine(9)and β-sitosterol(10),respectively.
CONCLUSIONS:
Compounds 1-4 are isolated from Rehmannia genus for the first time.
