Genistein 7-O-glucuronide

Genistein 7-O-glucuronide
Product Name Genistein 7-O-glucuronide
CAS No.: 38482-81-4
Catalog No.: CFN70353
Molecular Formula: C21H18O11
Molecular Weight: 446.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Estrogenic recepter
Source: The seeds of Glycine max
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Genistein 7-O-glucuronide has estrogenic potency.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Oncotarget.2015, 6(31):30831-49
  • LWT2020, 110397
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Antioxidants2022, 11(2),234.
  • Pharmaceutics2022, 14(2),376.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • BMC Complement Altern Med.2016, 16:213
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Metabolites.2023, 13(6):689.
  • Sci Rep.2019, 9(1):4646
  • Astrasieversianin VII

    Catalog No: CFN90648
    CAS No: 86764-11-6
    Price: $238/10mg
    Parishin E

    Catalog No: CFN93115
    CAS No: 952068-57-4
    Price: $298/20mg
    6-Methoxyluteolin

    Catalog No: CFN92706
    CAS No: 520-11-6
    Price: $268/20mg
    Catechin

    Catalog No: CFN99646
    CAS No: 154-23-4
    Price: $30/20mg
    3,4,5-Tricaffeoylquinic acid

    Catalog No: CFN90238
    CAS No: 86632-03-3
    Price: $318/5mg
    Toxicology in Vitro, 2015,29(4):706-715.
    Deconjugation of soy isoflavone glucuronides needed for estrogenic activity.[Reference: WebLink]
    Soy isoflavones (SIF) are present in the systemic circulation as conjugated forms of which the estrogenic potency is not yet clear.
    METHODS AND RESULTS:
    The present study provides evidence that the major SIF glucuronide metabolites in blood, genistein-7-O-glucuronide (GG) and Genistein 7-O-glucuronide (DG), only become estrogenic after deconjugation. The estrogenic potencies of genistein (Ge), daidzein (Da), GG and DG were determined using stably transfected U2OS-ERα, U2OS-ERβ reporter gene cells and proliferation was tested in T47D-ERβ cells mimicking the ERα/ERβ ratio of healthy breast cells and inT47D breast cancer cells. In all assays applied, the estrogenic potency of the aglycones was significantly higher than that of their corresponding glucuronides. UPLC analysis revealed that in U2OS and T47D cells, 0.2–1.6% of the glucuronides were deconjugated to their corresponding aglycones. The resulting aglycone concentrations can account for the estrogenicity observed upon glucuronide exposure. Interestingly, under similar experimental conditions, rat breast tissue S9 fraction was about 30 times more potent in deconjugating these glucuronides than human breast tissue S9 fraction.
    CONCLUSIONS:
    Our study confirms that SIF glucuronides are not estrogenic as such, and that the small % of deconjugation in the cell is enough to explain the slight bioactivity observed for the SIF-glucuronides. Species differences in deconjugation capacity should be taken into account when basing risk–benefit assessment of these SIF for the human population on animal data.
    Ganoderic acid L

    Catalog No: CFN95022
    CAS No: 102607-24-9
    Price: $413/5mg
    Leachianol F

    Catalog No: CFN95147
    CAS No: 164123-50-6
    Price: $318/5mg
    Epischisandrone

    Catalog No: CFN95212
    CAS No: 98619-26-2
    Price: $413/5mg
    Isolappaol C

    Catalog No: CFN95225
    CAS No: 929905-15-7
    Price: $333/10mg
    Tigloylgomisin O

    Catalog No: CFN95237
    CAS No: 130855-74-2
    Price: $368/5mg
    Batatasin V

    Catalog No: CFN95320
    CAS No: 65817-45-0
    Price: $318/5mg
    Japondipsaponin E1

    Catalog No: CFN95354
    CAS No: 175586-66-0
    Price: $318/5mg
    Oxytroflavoside D

    Catalog No: CFN95491
    CAS No: 1391144-83-4
    Price: $318/10mg
    Protocatechuic acid 4-O-beta-glucoside

    Catalog No: CFN95557
    CAS No: 7361-59-3
    Price: $413/5mg
    New compound 22

    Catalog No: CFN95570
    CAS No: N/A
    Price: $413/5mg