Ganoderic acid H

Ganoderic acid H
Product Name Ganoderic acid H
CAS No.: 98665-19-1
Catalog No.: CFN92056
Molecular Formula: C32H44O9
Molecular Weight: 572.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: NF-kB | AP-1 | CDK
Source: The fruit body of Ganoderma lucidum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Int J Vet Sci Med.2024, 12(1):134-147.
  • Oncol Rep.2019, 41(4):2453-2463
  • Molecular Simulation2023, 49(8):799-815.
  • HIV Med.2021, 22(8):690-704.
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Food Funct.2024, 15(8):4262-4275.
  • Trop J Nat Prod Res2023, 7(12):5611-5615.
  • Sci Rep.2023, 13(1):13072.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Antioxidants (Basel).2020, 9(11):1121.
  • Ganoderenic acid K

    Catalog No: CFN95469
    CAS No: 942950-94-9
    Price: $318/10mg
    Ganoderic acid C6

    Catalog No: CFN92290
    CAS No: 105742-76-5
    Price: $318/20mg
    Methyl ganoderate C6

    Catalog No: CFN92292
    CAS No: 105742-81-2
    Price: Inquiry(manager@chemfaces.com)
    Ganoderic acid H

    Catalog No: CFN92056
    CAS No: 98665-19-1
    Price: $318/10mg
    Methyl ganoderate H

    Catalog No: CFN92291
    CAS No: 98665-11-3
    Price: Inquiry(manager@chemfaces.com)
    Ganoweberianic acid E

    Catalog No: CFN95504
    CAS No: 1309931-90-5
    Price: $413/5mg
    12beta-Acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20-diene-26-oic acid

    Catalog No: CFN95468
    CAS No: 1085338-75-5
    Price: $318/5mg
    12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid

    Catalog No: CFN95505
    CAS No: 1309931-91-6
    Price: $318/5mg
    Deacetyl ganoderic acid F

    Catalog No: CFN90746
    CAS No: 100665-44-9
    Price: $358/5mg
    Ganoderic acid F

    Catalog No: CFN92055
    CAS No: 98665-15-7
    Price: $318/20mg
    Int J Mol Med. 2008 May;21(5):577-84.
    Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.[Pubmed: 18425349]
    Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, Ganoderic acid H), were identified in an oriental medicinal mushroom Ganoderma lucidum.
    METHODS AND RESULTS:
    In the present study we evaluated the effect of GA-A, Ganoderic acid H and GA-F on highly invasive human breast cancer cells. We showed that GA-A and Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Our results suggest that GA-A and Ganoderic acid H mediate their biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively. Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (Ganoderic acid H) in their triterpene lanostane structure.
    CONCLUSIONS:
    In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers.
    Nat Prod Res. 2014;28(24):2264-72.
    Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[Pubmed: 25032738]
    The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box-Behnken design.
    METHODS AND RESULTS:
    A quadratic model sufficiently simulated the response of Ganoderic acid H with a determination coefficient (R(2)) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at 60.22°C for 6.00 h, under which the yield of the reference triterpenoid Ganoderic acid H increased from 0.88 to 2.09 mg/g powder. Following extraction, triterpenoid-enriched fraction was further isolated into 23 fractions, and 7 fractions were identified as ganoderic acids A, B, D, G, H and I and ganoderenic acid D. Of the seven triterpenoids, ganoderenic acid D was most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. While ganoderic acids A, G and H were relatively non-cytotoxic.
    CONCLUSIONS:
    The variation of inhibitory effects for these triterpenoids was likely related to their chemical structures.
    Citrusin B

    Catalog No: CFN95178
    CAS No: 105279-10-5
    Price: $388/5mg
    Arganine B

    Catalog No: CFN95281
    CAS No: 144425-21-8
    Price: $318/5mg
    Cannabisin A

    Catalog No: CFN95287
    CAS No: 130508-46-2
    Price: $318/5mg
    Mucronulatol

    Catalog No: CFN95386
    CAS No: 20878-98-2
    Price: $318/5mg
    (2S)-5,7,3',4'-tetramethoxyflavanone

    Catalog No: CFN95406
    CAS No: 74628-43-6
    Price: $318/10mg
    Giganteone C

    Catalog No: CFN95484
    CAS No: 1071223-56-7
    Price: $318/10mg
    12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid

    Catalog No: CFN95505
    CAS No: 1309931-91-6
    Price: $318/5mg
    New compound 23

    Catalog No: CFN95587
    CAS No: N/A
    Price: $318/5mg
    N-Demethylfordianoside

    Catalog No: CFN95589
    CAS No: N/A
    Price: $318/10mg
    Resinacein D

    Catalog No: CFN95591
    CAS No: 2231061-47-3
    Price: $413/5mg