Product Name Galanolactone
CAS No.: 115753-79-2
Catalog No.: CFN99258
Molecular Formula: C20H30O3
Molecular Weight: 318.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: NO | 5-HT Receptor
Source: The rhizomes of Zingiber officinale Roscoe
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes.Galanolactone also shows cytotoxic activity .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-( S)-nerolidol and seven labdanes, coronarin B, galanal A and B, Galanolactone, ( E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-( E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact.
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    Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger.[Pubmed: 2054863]
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    In the present study, guinea pig ileum, rat stomach fundus and rabbit aortic strips are used in order to determine the constituents of fraction 2 which are responsible for anti-5-HT effect and to examine their pharmacological properties. The analysis of fraction 2-3 indicated that Galanolactone, a diterpenoid, is one of the active constituents. In guinea pig ileum, Galanolactone inhibited contractile responses to 5-HT with a pIC50 value 4.93. pIC50 value of Galanolactone against the response to 2-methyl-5-HT, a selective 5-HT3 agonist, in the presence of methysergide at 1 x 10(-5) M was 5.10. pIC50 values of ICS 205-930, a selective 5-HT3 antagonist, were 5.30 and 7.49, respectively. The concentration-response curve of 5-HT was shown as a biphasic curve and Galanolactone caused a selective shift to the right of the second phase. In the same preparations, the pIC50 value of Galanolactone and ICS 205-930 against the response to carbamylcholine (CCh) was 4.45 and 4.46. The inhibitory effect of Galanolactone on the 5-HT response in the stomach fundus and aortic strips was less than that in the ileum. In addition, in the thoracic aorta precontracted with 50 mM K+, the relaxing effect of Galanolactone was about 1/10 of that of papaverine.
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