Evofolin C
Evofolin C and its acetate show strong antifungal and antibacterial activity. Evofolin C exhibits potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Related and Featured Products
Phytochemistry. 1997 Jul;45(6):1207-12.
Prenylated phenylpropenes from Coleonema pulchellum with antimicrobial activity.[Pubmed:
9272968 ]
The lipophilic root extract of Coleonema pulchellum was analysed and tested for antifungal and antibacterial activity.
METHODS AND RESULTS:
Eight previously undescribed prenyloxy and geranyloxy phenylpropenes, were isolated as major compounds together with the known Evofolin C as well as the lignans (+/-)-sesamin and (+/-)-prenylpiperitol, the diterpene (-)-pimara-9(11),15-dien-19-oic acid and the 2,4-decadienoic acid isobutylamide. All structures were established by spectroscopic evidence.
CONCLUSIONS:
From the new phenylpropenes, named Evofolin C-acetate, colenemol, colenemal, prenycol acetate, dehydroprenycol acetate, precolpuchol, colpuchol and colpuchol acetate, the dihydroxylated precolpuchol displayed the strongest antifungal and antibacterial activity against Cladosporium herbarum and Staphylococcus aureus, respectively.
J Nat Prod. 2007 Sep;70(9):1444-8.
New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum.[Pubmed:
17822293 ]
METHODS AND RESULTS:
Five new compounds, including two new phenylpropenoids, (R,E)-1-[4-(3-hydroxyprop-1-enyl)phenoxy]-3-methylbutane-2,3-diol (1) and 4-hydroxy-3-(3-methyl-2-butenyl)cinnamyl alcohol (2), two new bis(1-phenylethyl)phenols, 2,6-bis(1-phenylethyl)phenol (3) and 2,4-bis(1-phenylethyl)phenol (4), and a new bisquinolinone alkaloid, 18-demethylparaensidimerin C (5), together with 17 known compounds have been isolated from the stem wood of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses including extensive 2D nuclear magnetic resonance data.
CONCLUSIONS:
Among the isolates, N-methylflindersine (7), (-)-simulanol (10), and Evofolin C (16) exhibited potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
Journal of Guangxi Teachers College, 2002 , 19 (2) :1-3.
Facile Synthesis of Evofolin C and Its Acetate[Reference:
WebLink]
METHODS AND RESULTS:
Evofolin C 1 and its acetate 2,two prenyloxy phenylpropen natural products isolated from Coleonema pulchellum Williams in South Africa with strong antifungal and antibacterial activity,were synthesized for the first time in four and five steps respectively staginging from isoprenol and 4_hydroxy benzaldehyde.
