Nelumol A

Nelumol A
Product Name Nelumol A
CAS No.: 77836-86-3
Catalog No.: CFN97873
Molecular Formula: C21H30O4
Molecular Weight: 346.5 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Powder
Targets: FXR
Source: The herbs of Zanthoxylum nitidum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • Applied Biological Chemistry2020, 63:33(2020)
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  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • Antimicrob Agents Chemother.2024, e0031424.
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    Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist.[Reference: WebLink]

    METHODS AND RESULTS:
    A series of 29 oxyprenylated and azoprenylated phenylpropanoids were chemically synthesized and tested in transfected cultured HepG2 cells by means of the dual-luciferase assay as farnesoid X receptor (FXR) agonists, using the endogenous ligand chenodeoxycholic acid (CDCA) as reference drug. Among the tested molecules, three compounds, namely auraptene, Nelumol A, and nelumal A showed a potency comparable to the endogenous ligand, with the latter natural product having a level of activity slightly superior to CDCA.
    CONCLUSIONS:
    Nelumal A is thus of interest as a valuable potential novel lead compound in the search for FXR agonists.
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