Deacetyleupaserrin
Deacetyleupaserrin is an antileukemic sesquiterpene lactone.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Planta Medica International2022, 9(01):e108-e115.
Chem Biol Interact.2019, 298:1-7
Nat Commun.2021, 12(1):681.
The Journal of Agromedicine and Medical Sciences2018, 4(1)
Prev Nutr Food Sci.2024, 29(4):563-571.
Natural Product Communications2020, doi: 10.1177.
Acta Chromatographica2016, 29(3)
J Int Med Res.2021, 49(7):3000605211032849.
Pharmacological Reports2020, 1-9
Metabolites2023, 13(1), 3.
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J Org Chem. 1973 Apr 6;38(7):1260-4.
The isolation and structural elucidation of eupaserrin and deacetyleupaserrin, new antileukemic sesquiterpene lactones from Eupatorium semiserratum[Reference:
WebLink]
Evidence is presented for the assignment of structures for eupaserrin (1) and Deacetyleupaserrin (5), two antileukemic sesquiterpene lactones from Eupatorium semiserratum DC.
METHODS AND RESULTS:
Elemental analysis and high resolution mass spectrometry supported a C22H28O7 molecular formula for eupaserrin (1) and a C20H26O6 molecular formula for Deacetyleupaserrin (5). Acetylation of 5 gave 1 and acetyleupaserrin (2), whereas alkaline hydrolysis of 5 gave sarracinic acid. Chemical and spectral evidence indicated the presence of α-methylene-γ-lactone, α,β-unsaturated ester, secondary hydroxyl, and two vinyl methyl groupings in 1 and 5 and suggested that both 1 and 5 were germacranolide dienes. Pyrolysis of 5 gave an oily aldehyde lactone (6), and pyrolysis of 2 gave an enol acetate (3).
CONCLUSIONS:
Chemical and spectral arguments are advanced for assignment of structure and stereochemistry for 2 and 3 and therefore 1 and 5.
