Durantoside I
Durantoside I has inhibitory activity on the growth of lettuce seedling. It also displays DPPH scavenging activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytochemical and phytotoxic investigation of the flowers from Citharexylum spinosum L.[Reference:
WebLink]
The aim of this study was to assess the phytotoxic potential of flowers of Citharexylum spinosum, as well as to isolate the main bioactive compounds.
METHODS AND RESULTS:
Results showed that the ethyl acetate extract induced the highest reduction, showing 100% inhibition of lettuce growth at 6000 ppm. This bioactive ethyl acetate extract was subjected to bio-guided chromatographic separation yielding the acetylated form of a new iridoid glucoside, designated as spinoside (1) together with two acetylated forms (2a) and (2b) of its known analogue Durantoside I (2).
CONCLUSIONS:
Their structures were established via their acetylated derivatives by means of spectroscopic and chemical data. The most inhibitory compound on the growth of lettuce seedling was identified to be the durantoside-I tetraacetylated (2b).
J. Pharm. Res.,2013,7(2):162-6.
New protein glycation inhibitory free radical scavenging compound from Duranta repens L.[Reference:
WebLink]
Hyperglycemia induced oxidative stress, increased generation of free radicals and free radicals mediated glycation of protein molecules are important events aggravating development of a number of diabetic complications.
To identify antiglycation principles with free radicals scavenging activities from traditional oriental medicinal plants.
METHODS AND RESULTS:
Biological activity ABTS+ radical scavenging in particular, guided isolation of active compounds was performed from methanolic extract of traditional oriental medicinal plants Duranta repense. Isolated compounds were further studied for their DPPH radical scavenging activity and advanced glycation end-products inhibitory potentials in vitro.
Activity guided isolation from methanolic extract of D. repens led to the identification of five iridoids namely Caryoptoside (1), Duraterectoside A (2), Durantoside III (3), Durantoside I (4), Lamiide (7) and two lignans namely (+) 5′Methoxyisolariciresinol (5), (−)5′Methoxyisolariciresinol (6). All the compounds scavenged ABTS+ radical, Caryoptoside (1) and (+) 5′Methoxyisolariciresinol (5) being most potent ABTS+ scavenger (IC50 = 6.0 and 3.1 μg/mL respectively). Only (+) 5′Methoxyisolariciresinol (5) displayed DPPH scavenging activity (IC50 = 70.5 μg/mL). Despite being potent ABTS+ scavenges, iridoid compounds rather augmented glucose induced formation of advanced glycation end-products in bovine serum albumin protein. (+) 5′Methoxyisolariciresinol (5) displayed both, the potent ABTS+ and DPPH scavenging activity however, showed mild (10%) antiglycation activity. On the other hand, (−) isomer of lignin 5′Methoxyisolariciresinol (6) that displayed moderate ABTS+ scavenging activity (IC50 = 42.6 μg/mL) potently inhibited (45%) glucose induced glycation of bovine serum albumin (BSA) protein.
CONCLUSIONS:
Methanol extract of D. repense possess potent antioxidant compounds. Iridoids augmented glucose induced glycation of BSA. Lignans displayed antiglycation activity. The (−) isomer of lignan 5′Methoxyisolariciresinol (6) was five times more potent in inhibiting glucose induced generation of AGEs in BSA.
Phytochemistry. 1995 Jul;39(4):829-33.
Iridoid glucosides from the leaves and stems of Duranta erecta.[Pubmed:
7626266]
METHODS AND RESULTS:
From the leaves of Duranta erecta, four new iridoid glucosides, duranterectosides A, B, C and D, were isolated along with Durantoside I and Durantoside II, lamiide, lamiidoside and verbascoside. Duranterectoside A was also isolated from the stems together with Durantoside I, II and III, and lamiidoside. The structures of the new compounds were elucidated based on the spectroscopic evidence.
