Daurinoline
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Phytochem Anal.2024, pca.3319.
RSC Advances2017, 86
Bioengineering2023, 10(10), 1113.
Appl. Sci.2020, 10(5),1713.
Plant Sci.2020, 301:110656.
J Ethnopharmacol.2017, 209:305-316
Int Immunopharmacol.2023, 125:111175.
Pak J Pharm Sci.2018, 31:311-315
Sci Rep.2019, 9(1):4342
Biomol Ther (Seoul).2020, 28(6):542-548.
Related and Featured Products
《Medical Journal of Wuhan University》 2011-01
Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice[Reference:
WebLink]
To investigate the effect of Daurinoline on cerebral pia mater microcirculation in mice.
METHODS AND RESULTS:
An open cranial window was performed and microcirculation disturbance state was established by means of administering noradrenaline on the cerebral pia mater. The effect of Daurinoline was observed from the changes of the diameters and numbers of the arterioles and venules. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
CONCLUSIONS:
It suggests that Daurinoline would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury.
Environ Toxicol Pharmacol . 2019 Feb;66:109-115.
Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol[Pubmed:
30641414]
Abstract
Non-small cell lung cancer (NSCLC) is one of the most common malignancies, and Taxol is a cornerstone in the treatment. However, taxol-resistance eventually limits the clinical effects and applications. Daurinoline could restore the sensitivity of resistant MCF-7/adr and KBv200 cells. Whereas, the effect of Daurinoline on the chemo-resistant NSCLC cells and the mechanism has not been elucidated. In this study, Daurinoline was firstly demonstrated that inhibited the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells. And these effects were associated with EMT and Notch-1 reversal. Moreover, Daurinoline could significantly enhance the anti-tumor effect of Taxol rather than epirubicin, adriamycin and cisplatin. And the reverse fold (RF) value of Daurinoline was greater than terfenadine reported before. There are little cytotoxic effects of Daurinoline and its derivatives reported by L.W. Fu, et al. (2001). Therefore, Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC patients.
Keywords: Chemosensitization; Daurinoline; EMT; Non-small cell lung cancer.
《Herald of Medicine》 2014-06
Relaxant Effect of Daurinoline on Vascular Smooth Muscle of Isolated Rabbit Basilar Artery[Reference:
WebLink]
To investigate the effect of Daurinoline on basilar artery vascular smooth muscle.
METHODS AND RESULTS:
The tension of isolated basilar artery ring of rabbit was measured. The effects of Daurinoline on the basilar artery contracted by methoxamine,5-hydroxytryptamine(5-HT),KCl and Histamine( His) were also examined. Dose-response curves of 5-HT and KCl were observed as well. Daurinoline exerted obvious relaxation effect on the basilar artery vascular ring contracted by methoxamine,5-HT,KCl and His in a concentration-dependent manner. IC50of Daurinoline in methoxamine,5-HT,KCl and His-treated rabbits was 8. 67 × 10- 5,1. 78 × 10- 6,6. 79 × 10- 7and 4. 98 × 10- 4mol · L- 1,respectively. The change of concentration-response curves of methoxamine,5-HT,KCl and His showed that Daurinoline was a non-competitive antagonist.
CONCLUSIONS:
Daurinoline exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism. The mechanism of relaxation action may be related to blockage of voltage-dependent or receptor-dependent calcium channels.
