Daurichromenic acid
Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nat Prod Commun. 2014 Sep;9(9):1329-32.
Daurichromenic acid-producing oxidocyclase in the young leaves of Rhododendron dauricum.[Pubmed:
25918805]
Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces Daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity.
METHODS AND RESULTS:
The Daurichromenic acid-producing enzyme, named Daurichromenic acid synthase, could be detected in the soluble protein fraction prepared from the young leaves of R. dauricum. Daurichromenic acid synthase catalyzed oxidocyclization of the farnesyl group of grifolic acid to form (+)-Daurichromenic acid as the major reaction product.
CONCLUSIONS:
The Daurichromenic acid synthase reaction proceeds without the need for any cofactors and coenzymes except for molecular oxygen. Interestingly, these catalytic properties of Daurichromenic acid synthase are quite similar to those reported for cannabinoid synthases in the marijuana plant Cannabis sativa L.
Org Lett. 2003 Nov 13;5(23):4481-4.
Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B.[Pubmed:
14602030]
METHODS AND RESULTS:
The highly potent anti-HIV natural product Daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular S(N)2'-type cyclization to form the 2H-benzopyran core structure.
