Daturametelin I

Daturametelin I
Product Name Daturametelin I
CAS No.: 904667-65-8
Catalog No.: CFN97468
Molecular Formula: C34H48O10
Molecular Weight: 616.8 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Datura tatura.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Reference standards.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Nutrients2020, 12(2):488
  • Onco Targets Ther.2017, 10:3467-3474
  • J of Essential Oil Research2019, 1677272
  • Industrial Crops and Products2018, 353-362
  • Oncotarget.2017, 8(53):90925-90947
  • Industrial Crops and Products2017, 95:286-295
  • J Food Compos Anal2017, 62:197-204
  • Anat Rec2018, 24264
  • Int J Mol Sci. 2014, 15(5):8443-57
  • J Agric Food Chem.2016, 64(35):6783-90
  • Jaborosalactone D

    Catalog No: CFN92969
    CAS No: 19891-82-8
    Price: Inquiry(manager@chemfaces.com)
    Withaferin A

    Catalog No: CFN91895
    CAS No: 5119-48-2
    Price: $318/10 mg
    Dihydrowithaferin A

    Catalog No: CFN91055
    CAS No: 5589-41-3
    Price: $258/5mg
    Withanolide S

    Catalog No: CFN96434
    CAS No: 63139-16-2
    Price: Inquiry(manager@chemfaces.com)
    Withanolide C

    Catalog No: CFN96435
    CAS No: 108030-78-0
    Price: Inquiry(manager@chemfaces.com)
    Withanolide A

    Catalog No: CFN91964
    CAS No: 32911-62-9
    Price: Inquiry(manager@chemfaces.com)
    6alpha-Chloro-5beta-hydroxywithaferin A

    Catalog No: CFN91967
    CAS No: 52329-20-1
    Price: $338/10mg
    Withanolide B

    Catalog No: CFN91963
    CAS No: 56973-41-2
    Price: Inquiry(manager@chemfaces.com)
    4beta-Hydroxywithanolide E

    Catalog No: CFN89289
    CAS No: 54334-04-2
    Price: Inquiry(manager@chemfaces.com)
    Somnifericin

    Catalog No: CFN95280
    CAS No: 173693-57-7
    Price: $318/5mg
    Chemistry & Biodiversity, 2006, 3(2):180-6
    Daturametelins H, I, and J: Three New Withanolide Glycosides from Datura metel L.[Reference: WebLink]

    METHODS AND RESULTS:
    Three new withanolide glycosides named daturametelins H, Daturametelin I, daturametelin J (1-3), together with two known ones, daturataturin A (4) and 7,27-dihydroxy-1-oxowitha-2,5,24-trienolide (5), were isolated from the MeOH extract of the aerial parts of Datura metel L. (Solanaceae). Their structures were determined mainly by spectroscopic techniques including 2D-NMR (HMBC, HMQC, (1)H,(1)H-COSY, NOESY) and MS experiments. Compounds 1-5 were tested for their antiproliferative activity towards the human colorectal carcinoma (HCT-116) cell line.
    CONCLUSIONS:
    The nonglycosidic compound 5 exhibited the highest activity of the tested withanolides, with an IC(50) value of 3.2+/-0.2 microM (Table 3).
    Frontiers in Pharmacology, 2018, 9:731.
    Metabolites Identification of Bioactive Compounds Daturataturin A, Daturametelin I, N-Trans-Feruloyltyramine, and Cannabisin F From the Seeds of Datura metel in Rats.[Reference: WebLink]
    Datura metel L. is a widely used traditional herbal medicine, and withanolides and amides are the two groups of main bioactive constituents in Datura metel seeds. This study aimed to elucidate the metabolism of four representative bioactive compositions containing daturataturin A (1), Daturametelin I (2), N-trans-feruloyltyramine (3), and cannabisin F (4) in rats.
    METHODS AND RESULTS:
    After separately oral administration of 20 mg/kg withanolides (1, 2) and amides (3, 4) to rats, a total of 12, 24, and 21 metabolites were detected in the plasma, urine, and fecal samples, respectively. Among them, three hydroxylated metabolites, 1-M3, 2-M2, and 3-M5, were detected in plasma and rat liver microsome incubation system in high abundance. Two metabolites of 1 and 2 were unambiguously identified by comparing with reference standards. Particularly, the methylated metabolite 27α-methoxy-(22R)-22,26-epoxy-27-[(β-D-glucopyranosyl)oxy]ergosta-2,4,6,24-tetraene-1,26-dione (daturametelin L) is a new compound.
    CONCLUSIONS:
    The withanolides could readily get hydroxylation or methylation metabolism. Meanwhile, the phase II metabolism (glucuronidation or sulfation) was the major reaction for the amides. This is the first study on in vivo metabolism of these active compounds in seeds of Datura metel.
    Morusinol

    Catalog No: CFN97086
    CAS No: 62949-93-3
    Price: $388/5mg
    Militarine

    Catalog No: CFN90409
    CAS No: 58139-23-4
    Price: $188/20mg
    Sophoraflavanone G

    Catalog No: CFN92005
    CAS No: 97938-30-2
    Price: $138/20mg
    Methylenetanshinquinone

    Catalog No: CFN92179
    CAS No: 67656-29-5
    Price: $338/5mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    Ginsenoside F5

    Catalog No: CFN95034
    CAS No: 189513-26-6
    Price: $298/20mg
    Yuanhuanin

    Catalog No: CFN95127
    CAS No: 83133-14-6
    Price: $318/5mg
    1-Phenyl-2-propanol

    Catalog No: CFN95129
    CAS No: 14898-87-4
    Price: $50/20mg
    (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate

    Catalog No: CFN95191
    CAS No: N/A
    Price: $318/5mg
    Isolappaol C

    Catalog No: CFN95225
    CAS No: 929905-15-7
    Price: $333/10mg