Dihydrowithaferin A

Dihydrowithaferin A
Product Name Dihydrowithaferin A
CAS No.: 5589-41-3
Catalog No.: CFN91055
Molecular Formula: C28H40O6
Molecular Weight: 472.6 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Physali alkekengi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $218/5mg
2, 3-Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors in human.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Mol Cell.2017, 68(4):673-685
  • J Med Food.2021, 24(3):209-217.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Antioxidants (Basel).2020, 9(7):581.
  • Analytical Letters 2021, 54(4).
  • Eur Endod J.2020, 5(1):23-27.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Somnifericin

    Catalog No: CFN95280
    CAS No: 173693-57-7
    Price: $318/5mg
    2,3-Didehydrosomnifericin

    Catalog No: CFN91969
    CAS No: 173614-88-5
    Price: $338/10mg
    Baimantuoluoside C

    Catalog No: CFN91965
    CAS No: 60124-17-6
    Price: $413/5mg
    Daturataturin A aglycone

    Catalog No: CFN97467
    CAS No: 904665-71-0
    Price: Inquiry(manager@chemfaces.com)
    Phyperunolide E

    Catalog No: CFN96990
    CAS No: 1198400-52-0
    Price: Inquiry(manager@chemfaces.com)
    Viscosalactone B

    Catalog No: CFN92968
    CAS No: 76938-46-0
    Price: Inquiry(manager@chemfaces.com)
    2,3-Dihydro-3-methoxywithaferin A

    Catalog No: CFN92965
    CAS No: 21902-96-5
    Price: Inquiry(manager@chemfaces.com)
    Daturametelin I

    Catalog No: CFN97468
    CAS No: 904667-65-8
    Price: Inquiry(manager@chemfaces.com)
    Daturataturin A

    Catalog No: CFN99414
    CAS No: 133360-51-7
    Price: Inquiry(manager@chemfaces.com)
    Withaperuvin C

    Catalog No: CFN96433
    CAS No: 81644-34-0
    Price: Inquiry(manager@chemfaces.com)
    Life Sci. 2003 Nov 21;74(1):125-32.
    Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.[Pubmed: 14575818]
    Ayurvedic medicines prepared in India consist of Withania somnifera roots as one of the main ingredients. It is consumed as a dietary supplement around the world. The leaves of W. somnifera were used in the treatment of tumors and inflammation in several Asian countries.
    METHODS AND RESULTS:
    We have isolated twelve withanolides such as withaferin A (1), sitoindoside IX (2), 4-(1-hydroxy-2, 2-dimethylcyclpropanone)-2, 3-Dihydrowithaferin A (3), 2, 3-Dihydrowithaferin A (4), 24, 25-dihydro-27-desoxywithaferin A (5), physagulin D (1-->6)-beta-D-glucopyranosyl- (1-->4)-beta-D-glucopyranoside (6), 27-O-beta-D-glucopyranosylphysagulin D (7), physagulin D (8), withanoside IV (9), and 27-O-beta-D-glucopyranosylviscosalactone B (10), 4, 16-dihydroxy-5beta, 6beta-epoxyphysagulin D (11), viscosalactone B (12) from the leaves of this species. Compounds 1-12 and diacetylwithaferin A (13) were tested for their antiproliferative activity on NCI-H460 (Lung), HCT-116 (Colon), SF-268 (Central Nervous System; CNS and MCF-7 (Breast) human tumor cell lines. The inhibitory concentration to afford 50% cell viability (IC50) for these compounds was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Withaferin A and its derivatives exhibited inhibitory concentrations (50%) ranging from 0.24 +/- 0.01 to 11.6 +/- 1.9 microg/mL. Viscosalactone B (12) showed the 50% inhibition at concentrations ranging from 0.32 +/- 0.05 to 0.47 +/- 0.15 microg/mL whereas its 27-O-glucoside derivative (10) exhibited IC50 between 7.9 +/- 2.9 and 17.3 +/- 3.9 microg/ml. However, Physagulin D type withanolides showed either weak or no activity at 30 microg/mL.
    CONCLUSIONS:
    Therefore, incorporation of withanolides in the diet may prevent or decrease the growth of tumors in human.
    Polygalasaponin XLIX

    Catalog No: CFN95117
    CAS No: 1033593-12-2
    Price: $318/10mg
    Methylgomisin O

    Catalog No: CFN95236
    CAS No: 1276654-07-9
    Price: $318/5mg
    2-Methoxy-1,4-naphthoquinone

    Catalog No: CFN95269
    CAS No: 2348-82-5
    Price: $70/20mg
    9,11-Dehydro-beta-boswellic acid

    Catalog No: CFN95335
    CAS No: 471-65-8
    Price: $318/5mg
    3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone

    Catalog No: CFN95397
    CAS No: 29976-51-0
    Price: $318/5mg
    4'-Hydroxy-5,7,3'-trimethoxyflavone

    Catalog No: CFN95398
    CAS No: 1239-68-5
    Price: $318/5mg
    Elgonica dimer A

    Catalog No: CFN95445
    CAS No: 132210-48-1
    Price: $368/5mg
    Barbaloin-related compound A

    Catalog No: CFN95453
    CAS No: 473225-21-7
    Price: $318/5mg
    Ganoweberianic acid E

    Catalog No: CFN95504
    CAS No: 1309931-90-5
    Price: $413/5mg
    New compound 18

    Catalog No: CFN95527
    CAS No: N/A
    Price: $413/5mg