D-Serine

D-Serine
Product Name D-Serine
CAS No.: 312-84-5
Catalog No.: CFN70097
Molecular Formula: C3H7NO3
Molecular Weight: 105.0 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: NMDA receptor
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $30/20mg
D-serine is an endogenous modulator of the glycine site of NMDA receptors. D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8. It also could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Chromatogr Sci.2015, 53(5):824-9
  • Nutrients.2019, 11(4):E936
  • J Ethnopharmacol.2016, 192:370-381
  • University of Limpopo2016, 1-237
  • J Inflamm Res.2022, 15:5347-5359.
  • Anat Rec2018, 24264
  • Toxins (Basel).2022, 14(12):824.
  • BMC Complement Altern Med.2019, 19(1):367
  • Horticulturae2023, 9(2), 213.
  • Sci Rep. 2018, 1-9
  • Sophoricoside

    Catalog No: CFN90148
    CAS No: 152-95-4
    Price: $40/20mg
    Vitexin-2''-O-rhamnoside

    Catalog No: CFN98177
    CAS No: 64820-99-1
    Price: $118/20mg
    Kaempferol 3-O-arabinoside

    Catalog No: CFN97572
    CAS No: 99882-10-7
    Price: $338/5mg
    Stigmasterol

    Catalog No: CFN97326
    CAS No: 83-48-7
    Price: $30/20mg
    25S-Inokosterone

    Catalog No: CFN93571
    CAS No: 19595-18-7
    Price: $318/10mg
    Proc Natl Acad Sci U S A,2000 Apr 25;97(9):4926-31.
    D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.[Pubmed: 10781100]
    Functional activity of N-methyl-D-aspartate (NMDA) receptors requires both glutamate binding and the binding of an endogenous coagonist that has been presumed to be glycine, although D-Serine is a more potent agonist. Localizations of D-Serine and it biosynthetic enzyme serine racemase approximate the distribution of NMDA receptors more closely than glycine.
    METHODS AND RESULTS:
    We now show that selective degradation of D-Serine with D-amino acid oxidase greatly attenuates NMDA receptor-mediated neurotransmission as assessed by using whole-cell patch-clamp recordings or indirectly by using biochemical assays of the sequelae of NMDA receptor-mediated calcium flux. The inhibitory effects of the enzyme are fully reversed by exogenously applied D-Serine, which by itself did not potentiate NMDA receptor-mediated synaptic responses.
    CONCLUSIONS:
    Thus, D-Serine is an endogenous modulator of the glycine site of NMDA receptors and fully occupies this site at some functional synapses.
    Proc Natl Acad Sci U S A,1995 Apr 25;92(9):3948-52.
    D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.[Pubmed: 7732010]

    METHODS AND RESULTS:
    Using an antibody highly specific for D-Serine conjugated to glutaraldehyde, we have localized endogenous D-Serine in rat brain. Highest levels of D-Serine immunoreactivity occur in the gray matter of the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdala. Localizations of D-Serine immunoreactivity correlate closely with those of D-Serine binding to the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor as visualized by autoradiography and are inversely correlated to the presence of D-amino acid oxidase. D-Serine is enriched in process-bearing glial cells in neuropil with the morphology of protoplasmic astrocytes. In glial cultures of rat cerebral cortex, D-Serine is enriched in type 2 astrocytes.
    CONCLUSIONS:
    The release of D-Serine from these cultures is stimulated by agonists of non-NMDA glutamate receptors, suggesting a mechanism by which astrocyte-derived D-Serine could modulate neurotransmission. D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors.
    Neuropsychopharmacology, 2008, 33(5):1004-1018.
    D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning.[Pubmed: 17625504]
    The contributions of hippocampal long-term depression (LTD) to explicit learning and memory are poorly understood. Electrophysiological and behavioral studies examined the effects of modulating NMDA receptor-dependent LTD on spatial learning in the Morris water maze (MWM).
    METHODS AND RESULTS:
    The NMDA receptor co-agonist D-Serine substantially enhanced NR2B-dependent LTD, but not long-term potentiation (LTP) or depotentiation, in hippocampal slices from adult wild type mice. Exogenous D-Serine did not alter MWM acquisition, but substantially enhanced subsequent reversal learning of a novel target location and performance in a delayed-matching-to-place task. Conversely, an NR2B antagonist disrupted reversal learning and promoted perseveration. Endogenous synaptic D-Serine likely saturates during LTP induction because exogenous D-Serine rescued deficient LTP and MWM acquisition in Grin1(D481N) mutant mice having a lower D-Serine affinity.
    CONCLUSIONS:
    Thus, D-Serine may enhance a form of hippocampal NR2B-dependent LTD that contributes to spatial reversal learning. By enhancing this form of synaptic plasticity, D-Serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors.
    Neurosci Lett,2005 Apr 29;379(1):7-12.
    D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.[Pubmed: 15814189]
    The molecular and cellular mechanisms underlying the cognitive deficiency of senescence-accelerated mouse prone/8 (SAMP8) have been attributed to many pathological changes in neurons. Recently, increasing evidence has shown that astrocytes, by mean of D-Serine, involve in the process of synaptic transmission.
    METHODS AND RESULTS:
    Here we reported that the long-term potentiation (LTP) in CA1 area of hippocampal slices prepared from 2-, 6- and 12-month-old SAMP8 significantly decreased with age. Meanwhile, the LTP in the slices of 6- and 12-month-old mice markedly decreased below that of the age-matched normal strain SAMR1. Supplement with exogenous D-Serine, a main product of astrocytes and a coagonist at the "glycin-binding" site of N-methyl-d-aspartate (NMDA) receptors, not only directly enhanced the deficient LTP but also rescued the abolished LTP by d-amino acid oxidase (DAAO) in slices from 12-month-old SAMP8. This ameliorative effect of D-Serine was inhibited by either AP-V or 5,7-dichlorokynurenic acid (DCKA).
    CONCLUSIONS:
    These results suggest that absence of D-Serine or dysfunction of the astrocytes possibly was one of mechanisms underlying the decrease of NMDA receptor-dependent LTP and cognition in aged SAMP8.
    Lappaol A

    Catalog No: CFN95067
    CAS No: 62333-08-8
    Price: $333/10mg
    Lappaol F

    Catalog No: CFN95069
    CAS No: 69394-17-8
    Price: $368/10mg
    Biatractylolide

    Catalog No: CFN95205
    CAS No: 182426-37-5
    Price: $268/10mg
    3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside

    Catalog No: CFN95228
    CAS No: 51768-39-9
    Price: $413/5mg
    8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid

    Catalog No: CFN95308
    CAS No: 69790-31-4
    Price: $318/5mg
    Tortoside B (Manglieside E)

    Catalog No: CFN95390
    CAS No: 190655-17-5
    Price: $413/5mg
    10-O-trans-p-coumaroylscandoside

    Catalog No: CFN95391
    CAS No: 870785-25-4
    Price: $318/10mg
    Gambogoic acid A

    Catalog No: CFN95439
    CAS No: 887923-49-1
    Price: $318/10mg
    Ganoderic acid GS-3

    Catalog No: CFN95518
    CAS No: 1206781-66-9
    Price: $413/5mg
    Methyl ganoderenate D

    Catalog No: CFN95572
    CAS No: 748136-03-0
    Price: $413/5mg