Cynatratoside A
Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Parasitology. 2017 Feb;144(2):179-185.
Activity of two extracts of Cynanchum paniculatum against Ichthyophthirius multifiliis theronts and tomonts.[Pubmed:
27928976]
METHODS AND RESULTS:
The present study aims to evaluate the antiparasitic activity of active components from Cynanchum paniculatum against Ichthyophthirius multifiliis. The antiparasitic activities of two bioassay-guided fractionationated compounds from C. paniculatum identified as Cynatratoside A and Cynanversicoside C, by comparing spectral data (NMR and ESI-MS) with literature values, were evaluated by in vitro assay. These showed that both could kill theronts of I. multifiliis at a concentration of 10·0 mg L-1, with the median effective concentration (EC50) values of 4·6 mg L-1 and 5·2 mg L-1 for Cynatratoside A and Cynanversicoside C, respectively. Encysted tomonts were killed at concentrations of 8·0 mg L-1 with both compounds. In vivo experiments demonstrated that fish treated with both compounds at 15·0 mg L-1 carried significantly fewer parasites than controls (P < 0·05).
CONCLUSIONS:
There were no mortalities among treated fish group compared with 75% mortality of untreated fish. Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against I. multifiliis.
J Asian Nat Prod Res. 2016;18(4):339-43.
Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum.[Pubmed:
26465069 ]
METHODS AND RESULTS:
Two new 13,14:14,15-disecopregnane-type compounds glaucogenin F (1), glaucogenin F 3-O-β-D-oleandropyranoside (2), together with three known compounds cynapanoside A (3), Cynatratoside A (4), and neocynapanogenin F 3-O-β-D-oleandropyranoside (5) were isolated from the 95% ethanol extract of the roots of Cynanchum paniculatum.
CONCLUSIONS:
The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HRESIMS and NOESY.
