Cyclomusalenone
Cyclomusalenone is a potent α-glucosidase inhibitor.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Medicinal Chemistry Research. 2015 May;24(5):2177-2182.
Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors.[Reference:
WebLink]
METHODS AND RESULTS:
A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of Cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been established by an NMR spectroscopy analysis, and inhibitory activity against α-glucosidase was evaluated.
CONCLUSIONS:
Among tested compounds, 2,3-isoxazoloCyclomusalenone is discovered as a new potent α-glucosidase inhibitor with IC50 value 20.4 μM being 30- and 20-fold more active than initial Cyclomusalenone and marketed drug acarbose.
Chemical & pharmaceutical bulletin.1997 Apr15; 45(4):744-746.
4-Epicycloeucalenone and 4-Epicyclomusalenone : Two 3-Oxo-28-norcycloartanes from the Fruit Peel of Musa sapientum L.[Reference:
WebLink]
METHODS AND RESULTS:
Two 3-oxo-28-norcycloartane-type triterpenes, 4-epicycloeucalenone and 4-epiCyclomusalenone, and two known 3-oxo-29-norcycloartanes, cycloeucalenone and Cyclomusalenone, were isolated from the n-hexane extract of the fruit peel of Musa sapientum L. (banana). The structures of the 28-norcycloartanes were determined by spectroscopic and chemical methods.
