Cyclo(Tyr-Gly)
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Studies in Organic Chemistry, 1998, 53(98):167-171.
Microbial degradation of 2,5-diketopiperazines.[Reference:
WebLink]
METHODS AND RESULTS:
Enrichment culture of soil samples with cyclo(Gly-Gly) and cyclo(Gly-l-Tyr) as a carbon and/or a nitrogen source resulted in the isolation of Arthrobacter sp. 1-3-1 and the coryneform rod bacterium, strain T-1-3-Y, as the bacteria which most highly assimilated cyclo(Gly-Gly) and cyclo(Gly-l-Tyr), respectively. Both bacteria had the enzyme activity hydrolyzing DKPs intracellularly in contrast to the extracellular cyclo(Gly-Gly) hydrolase reported previously. The cells of Arthrobacter sp. 1-3-1 degraded all diketopiperazines tested, including cyclo(Gly-Gly), cyclo(Gly-l-Ala), cyclo(Gly-l-Val), cyclo(Gly-l-Leu), cyclo(Gly-l-Ile), cyclo(Gly-l-Met), cyclo(Gly-l-Phe), cyclo(Gly-l-Tyr)(Cyclo(Tyr-Gly)), cyclo(l-Ala-l-Tyr), cyclo(l-Val-l-Tyr), cyclo(l-Leu-l-Tyr), cyclo(l-Tyr-l-Tyr), cyclo(l-Phe-l-Leu), cyclo(Gly-d-Ala), and cyclo(Gly-d-Leu). On the other hand, the degradation of d-amino acid-containing DKPs or cyclo(Gly-Gly) by the cells of the strain T-1-3-Y were detected hardly or not at all, respectively.
CONCLUSIONS:
From the result that DKP hydrolase in the strain T-1-3-Y had a higher stereospecificity than that in Arthrobacter sp. 1-3-1, the diversity of DKP hydrolases were found to be in nature.
Chinese Journal of Antibiotics, 2005-08.
Antitumor components from marine actinomycete 11014: I. Cyclic dipeptides.[Reference:
WebLink]
METHODS AND RESULTS:
To explore the antitumor active components in fermentation of a marine actinomycete 11014, 13 cyclic dipetides were isolated and purified by using solvent extraction, silica gel column and preparation HPLC. The separation procedure was guided by a bioassay using tsFT210 cell lines. By means of physicochemical properties and spectral analysis, their structures were respectively determined as: cyclo-(Leu-Ala), cyclo-(Leu-Gly), cyclo-(Ile-Ala), cyclo-(Val-Ala), cyclo-(Ala-Phe), cyclo-(Phe-Gly), Cyclo(Tyr-Gly), cyclo-(Pro-Tyr), cyclo-(Pro-Phe), cyclo-(4-hydroxyl-Pro-Phe), cyclo-(4-hydroxyl-Pro-Leu), cyclo-(Pro-Val), cyclo-(Pro-Leu). The antitumor activities of these compounds were firstly assayed by sulfo rhodamine B method.
CONCLUSIONS:
Cyclo-(4-hydroxyl-Pro-Phe) showed cytotoxicity against tsFT210 cell lines with inhibitory rate of 48. 3% at the concentration of 5 μg/ml.
